1. 重组蛋白
  2. Ubiquitin Related Proteins
  3. Deubiquitinase
  4. Ubiquitin-Specific Protease
  5. Ubiquitin-Specific Peptidase 46
  6. USP46 蛋白, Human/Mouse (sf9, SUMO)

USP46 蛋白, Human/Mouse (sf9, SUMO)

目录号: HY-P77278
产品使用指南

USP46 蛋白是一种泛素特异性蛋白酶,参与细胞过程和蛋白质降解的调节。人们发现它在突触可塑性和记忆形成中发挥着关键作用。USP46 蛋白作为认知障碍治疗靶点的潜力及其对神经功能的影响使其成为神经科学研究的热点。USP46 蛋白, Human/Mouse (sf9, SUMO) 是重组的 USP46 蛋白,由 Sf9 insect cells 表达,带有 SUMO 标签。USP46 蛋白, Human/Mouse (sf9, SUMO) 全长 366 个氨基酸,分子量约为 ~64 kDa。

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重组蛋白定制服务

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

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描述

USP46 Protein, a ubiquitin-specific protease, is involved in the regulation of cellular processes and protein degradation. It has been found to play a critical role in synaptic plasticity and memory formation. USP46 Protein's potential as a therapeutic target in cognitive disorders and its impact on neurological function make it a subject of interest in neuroscience research. USP46 Protein, Human/Mouse (sf9, SUMO) is the recombinant mouse-derived USP46 protein, expressed by Sf9 insect cells , with SUMO labeled tag. The total length of USP46 Protein, Human/Mouse (sf9, SUMO) is 366 a.a., with molecular weight of ~64 kDa.

研究背景

USP46 蛋白是一种去泛素化酶,可能通过调节 GABA 作用参与行为调节。研究表明,其作用可能涉及介导 GAD1/GAD67 的去泛素化。有趣的是,USP46 本身表现出最小的去泛素化活性,并依赖与 WDR48 的相互作用来实现高酶活性。与参与 GABA 相关过程相反,USP46 不参与单泛素化 FANCD2 的去泛素化,表明其底物相互作用具有特异性(通过相似性)。这种多方面的酶揭示了行为和神经递质动力学背后的复杂调节机制。

种属

Mouse

表达系统

Sf9 insect cells

标签

SUMO

蛋白编号

P62069 (M1-E366)

基因 ID

69727  [NCBI]

同用名
Ubiquitin carboxyl-terminal hydrolase 46; Deubiquitinating enzyme 46; Usp46
分子量

Approximately 64 kDa

纯度

Greater than 90% as determined by reducing SDS-PAGE

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
USP46 Protein, Human/Mouse (sf9, SUMO)
目录号:
HY-P77278
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