XTP3TPA 蛋白, Human (His)

XTP3TPA protein crucially hydrolyzes deoxynucleoside triphosphates (dNTPs), particularly preferring dCTP and its analogs, like 5-iodo-dCTP and 5-methyl-dCTP. This selective hydrolysis, reflecting high efficiency, likely safeguards against the incorporation of genotoxic nucleotide analogs into DNA or RNA, contributing to genomic integrity and protecting cellular nucleotide pools. XTP3TPA Protein, Human (His) is the recombinant human-derived XTP3TPA protein, expressed by E. coli , with N-His labeled tag. The total length of XTP3TPA Protein, Human (His) is 170 a.a., with molecular weight of ~19 kDa.

XTP3TPA 蛋白通过将脱氧核苷三磷酸 (dNTP) 水解为其相应的核苷一磷酸，在细胞过程中发挥至关重要的作用。该酶对 dCTP 及其类似物（例如 5-碘-dCTP 和 5-甲基-dCTP）表现出强烈的偏好，表现出高效率，可能作为防止基因毒性核苷酸类似物掺入 DNA 或 RNA 的保护机制。XTP3TPA 对这些核苷酸三磷酸的选择性水解有助于维持基因组完整性，并可能在保护细胞核苷酸库免受潜在有害类似物侵害方面发挥作用。

Human

E. coli

N-His

Q9H773 (M1-T170)

79077  [NCBI]

MSVAGGEIRGDTGGEDTAAPGRFSFSPEPTLEDIRRLHAEFAAERDWEQFHQPRNLLLALVGEVGELAELFQWKTDGEPGPQGWSPRERAALQEELSDVLIYLVALAARCRVDLPLAVLSKMDINRRRYPAHLARSSSRKYTELPHGAISEDQAVGPADIPCDSTGQTST

Approximately 19 kDa

Greater than 95% as determined by reducing SDS-PAGE

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of 50 mM Tris, 300 mM NaCl, 5% trehalose, 5% mannitol and 0.01% Tween80, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.