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  2. 化合物库
  3. 生物活性化合物库系列
  4. 疾病相关化合物库
  5. 肿瘤免疫小分子化合物库
肿瘤免疫小分子化合物库 - Small Molecule Immuno-Oncology Compound Library

Cat. No.: HY-L031

肿瘤免疫(Immuno-oncology,I-O)是一种专门针对癌症的免疫疗法。该疗法通过刺激我们的免疫系统对肿瘤细胞产生抵抗。正常情况下,我们的免疫系统能够清除体内的肿瘤细胞,但有时肿瘤细胞可以适应体内环境并产生变异,有效地逃逸免疫系统的监视。这时,肿瘤就会进一步发展并威胁到我们的健康。肿瘤免疫疗法可以利用免疫系统,调动淋巴细胞识别和清除肿瘤细胞。目前有多种可利用的肿瘤免疫疗法,包括免疫细胞治疗(CAR-T)、单克隆抗体和免疫检查点抑制剂、细胞因子及癌症疫苗等。

MCE 提供 484 种肿瘤免疫相关化合物,主要靶向 PD1/PD-L1、CXCR、Sting、IDO、TLR 等重要免疫检查点,是研究肿瘤免疫的有用工具。

我们将在明确您的产品用途后,向符合资质的客户通过定制合成服务的方式提供 MCE 肿瘤免疫小分子化合物库,我们为该库中的所有产品提供溶液包装或粉末包装。溶液包装中,471 个产品以 10 mM 浓度提供,10 个产品以 2 mM 浓度提供,3 个产品以 3 mg/mL 浓度提供。

溶液包装中,我们对于溶液状态稳定且溶解度不低于 10 mM 的产品,提供 10 mM 溶液;对于溶液状态稳定且溶解度介于 2~10 mM 的产品,我们提供 2 mM 溶液;对于溶液状态稳定、分子量不确定且溶解度不低于 3 mg/mL产品,我们提供 3 mg/mL 溶液。

  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
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Compound Screening Libraries

Top Publications Citing Use of MCE Products

MCE 顾客使用化合物库产品发表的文献

  • 生物活性
  • 产品详情
  • 产品资料
  • 化合物库组成

活性描述 & 特点

Biological Activity

•   A unique collection of 484 bioactive tumor immunology compounds for high throughput screening (HTS) and high content screening (HCS).

•   A useful tool for cancer research by activation of an antitumor immune response.

•   Small molecule compounds targeting PD1/PD-L1, ROR, CCR, CXCR, Sting, IDO, TLR, etc.

•   Bioactivity and safety confirmed by preclinical research and clinical trials, some have been approved by FDA.

•   Structurally diverse, medicinally active, and cell permeable.

•   More detailed compound information with structure, IC50, and other chemical & biological data.

•   NMR and HPLC validated to ensure high purity and quality.

•   All compounds are in stock and continuously updated.

产品详情

Product Details

Formulation:

A collection of 484 bioactive tumor immunology compounds supplied as pre-dissolved Solutions or Solid
Solution: 471 compounds supplied in 10 mM solution, 10 compounds supplied in 2 mM solution, 3 compounds supplied in 3 mg/mL solution.

Layout:

96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates. This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.

Container:

96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode

Storage:

-80°C

Shipping:

Blue ice

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  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack

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    产品名称:
    Small Molecule Immuno-Oncology Compound Library
    目录号:
    HY-L031
    需求量: