2. 一站式药筛
  3. 化合物库
  4. 生物活性化合物库系列
  5. 疾病相关化合物库
  6. 抗血液肿瘤化合物库
抗血液肿瘤化合物库 - Anti-Blood Cancer Compound Library

Cat. No.: HY-L079

血液肿瘤是指发生在血液系统中的恶性肿瘤，主要发病机理为异常血细胞生长失去控制，正常血细胞抵抗感染并产生新的血细胞的功能受限。大多数血液肿瘤开始于骨髓。临床上常见的血液肿瘤主要有三种类型:白血病、淋巴瘤和骨髓瘤，这些癌症每年折磨着数百万儿童和成年人，而且往往是致命的。

一些常见的血液肿瘤治疗方法包括干细胞移植、化疗、放疗、靶向治疗、免疫治疗或几种治疗方法的结合。随着我们对血液疾病恶性转化的关键信号通路和分子驱动因素的逐步了解，新的血液肿瘤治疗策略将不断被开发。

MCE 提供 2676 个具有明确或潜在抗血液肿瘤活性的化合物，这些化合物靶向血液肿瘤治疗中的关键靶点及信号通路，是筛选抗血液肿瘤活性化合物及其他相关研究的重要工具。

我们将在明确您的产品用途后，向符合资质的客户通过定制合成服务的方式提供 MCE 抗血液肿瘤化合物库，我们为该库中的所有产品提供溶液包装或粉末包装。溶液包装中，2621 个产品以 10 mM 浓度提供，52 个产品以 2 mM 浓度提供，3 个产品以 3 mg/mL 浓度提供。

溶液包装中，我们对于溶液状态稳定且溶解度不低于 10 mM 的产品，提供 10 mM 溶液；对于溶液状态稳定且溶解度介于 2~10 mM 的产品，我们提供 2 mM 溶液；对于溶液状态稳定、分子量不确定且溶解度不低于 3 mg/mL产品，我们提供 3 mg/mL 溶液。

  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
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Compound Screening Libraries

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MCE 顾客使用化合物库产品发表的文献

  • 生物活性
  • 产品详情
  • 产品资料
  • 化合物库组成

活性描述 & 特点

Biological Activity

•   A unique collection of 2676 compounds with identified and potential anti-blood cancer activity for high throughput screening (HTS) and high content screening (HCS).

•   Targets include FLT3, Bcr-Abl, JAK, PI3K, PD-1/PD-L1, etc.

•   A useful tool for the discovery of anti-blood cancer drugs.

•   Bioactivity and safety confirmed by preclinical research and clinical trials. Some have been approved by FDA.

•   Structurally diverse, medicinally active, and cell permeable.

•   Detailed compound information with structure, IC50, and brief introduction.

•   Validated NMR and HPLC to ensure high purity and quality.

•   All compounds are in stock and continuously updated.

产品详情

Product Details

Formulation:

A collection of 2676 anti-blood cancer compounds supplied as pre-dissolved Solutions or Solid
Solution: 2621 compounds supplied in 10 mM solution, 52 compounds supplied in 2 mM solution, 3 compounds supplied in 3 mg/mL solution.

Layout:

96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates. This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.

Container:

96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode

Storage:

-80°C

Shipping:

Blue ice

化合物库组成

Composition

CDK (241)

NF-κB (233)

PI3K (178)

VEGFR (151)

HDAC (123)

JAK (115)

Akt (104)

STAT (97)

mTOR (91)

Ras (91)

FLT3 (82)

PDGFR (68)

c-Kit (59)

Btk (57)

HIV (40)

FGFR (38)

Src (32)

EGFR (31)

COX (28)

GSK-3 (25)

ERK (23)

AMPK (18)

HSV (18)

c-Fms (14)

JNK (13)

PKC (13)

Raf (12)

RET (12)

Syk (12)

MMP (11)

HSP (10)

FAK (8)

IRAK (8)

DYRK (7)

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  •  特定化合物
  •  化合物数量
  •  产品排布图
  •  浓度
  •  形式（固体或溶液）
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联系专家定制
  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack

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    Anti-Blood Cancer Compound Library
    目录号：
    HY-L079
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