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  2. Bacterial
  3. VNRX-5133

VNRX-5133 

目录号: HY-120065
产品使用指南

VNRX-5133 是 β-内酰胺酶抑制剂。VNRX-5133 对丝氨酸活性位点 β-内酰胺酶 (Ser-BL) 和金属-β-内酰胺酶 (MBL) 具有直接抑制活性。VNRX-5133 对多药耐药的肺炎克雷伯菌 (K. pneumonia) 和绿脓杆菌 (P. aeruginosa) 临床分离株具有高活性。

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VNRX-5133 Chemical Structure

VNRX-5133 Chemical Structure

CAS No. : 1613268-23-7

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Description

VNRX-5133 is a cyclic boronate β-lactamase inhibitor. VNRX-5133 has direct inhibitory activity against serine-active site β-lactamases (Ser-BL) and metallo-β-lactamases (MBL). VNRX-5133 is highly active against multidrug-resistant (MDR)-K. pneumonia and P. aeruginosa clinical isolates[1].

IC50 & Target

β-lactamase[1]

In Vitro

VNRX-5133 is a potent β-lactamase inhibitor (BLI) possessing a unique broad spectrum of activity, including Class A, C, and D Ser-BLs. VNRX-5133 enhances the activity of Cefepime against resistant Enterobacteriaceae and P. aeruginosa isolates in a neutropenic mouse-thigh infection model[1].

Clinical Trial
Molecular Weight

389.25

Formula

C₁₉H₂₈BN₃O₅

CAS No.

1613268-23-7

SMILES

OC(C1=C2C(C[C@@H](NC(C[C@@H]3CC[C@@H](NCCN)CC3)=O)B(O)O2)=CC=C1)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
VNRX-5133
目录号:
HY-120065
需求量:

VNRX-5133

Cat. No.: HY-120065