1. Anti-infection
  2. Beta-lactamase Bacterial
  3. Taniborbactam

Taniborbactam  (Synonyms: VNRX-5133)

目录号: HY-109124
产品使用指南

Taniborbactam (VNRX-5133) 是一种可逆的,选择性的含硼酸全光谱 β-内酰胺酶 (β-lactamase) 抑制剂,IC50 为 8-530 nM。Taniborbactam 对 KPC-2,AmpC,OXA-48 和 VIM-2 的 IC50 分别为 30 nM,32 nM,42 nM,20 nM。Taniborbactam 具有抗革兰氏阴性菌 (bacteria) 活性。

在相同的摩尔浓度下,化合物盐形式与游离形式有相同的生物活性,但盐形式 Taniborbactam hydrochloride 通常具有更好的水溶性和稳定性。

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Taniborbactam Chemical Structure

Taniborbactam Chemical Structure

CAS No. : 1613267-49-4

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Taniborbactam (VNRX-5133) is a reversible and selective boronic acid-containing pan-spectrum β-lactamase inhibitor with IC50s of 8-530 nM. Taniborbactam has IC50s of 30 nM, 32 nM, 42 nM, 20 nM for KPC-2, AmpC, OXA-48, and VIM-2. Taniborbactam is against Gram-negative bacteria[1][2].

IC50 & Target

β-lactamase[1]

体外研究
(In Vitro)

Taniborbactam (VNRX-5133) has IC50s of 0.5 nM, 2 nM, 0.5 nM, 0.06 nM for KPC-2, OXA-48, VIM-4 of K.pneumoniae strain and VIM-2 of P.aeruginosa strain[2].
Both cefepime/Taniborbactam (10 μg/mL) and meropenem/Taniborbactam combinations are highly active against all six of the NDM-1-producing clinical isolates from K.pneumoniae and E.coli, with MIC ranges of 16-0.25 and 1-0.125 μg/mL, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

A single dose of cefepime (32 mg/kg)/Taniborbactam (VNRX-5133; 16 mg/kg; s.c.) achieves >4 log10 reduction in viable bacterial counts in the neutropenic mouse lung infection model against a CTX-M-14-producing strain of K.pneumoniae[2].
Combination of Cefepime (16 mg/kg) and Taniborbactam (16 mg/kg; s.c.; twice-a-day for 7 days) demonstrates >2 log10 reductions in viable bacterial counts in the kidney of the ascending urinary tract infection model against a CTX-M-15-producing strain of E.coli[2].
Taniborbactam has a T1/2 of 0.16 hours, a CL of 618 mL/h/kg, and a Vss of 143 mL/kg for mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
分子量

389.25

Formula

C19H28BN3O5

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

Taniborbactam 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Taniborbactam
目录号:
HY-109124
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