2. Apoptosis Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  3. Ferroptosis Reactive Oxygen Species (ROS)
  4. 1,4-Naphthoquinone-NH-C2-NH-Trolox

1,4-Naphthoquinone-NH-C2-NH-Trolox 是一种具有神经保护活性的可穿透血脑屏障的 Trolox (HY-101445) 和维生素 K (HY-B2172) 的结合物。1,4-Naphthoquinone-NH-C2-NH-Trolox 能够抑制氧化死亡 (oxytosis)、铁死亡 (ferroptosis)、ATP 耗竭以及活性氧 (ROS) 的产生。1,4-Naphthoquinone-NH-C2-NH-Trolox 可选择性抑制 M1 标志物的表达。1,4-Naphthoquinone-NH-C2-NH-Trolox 可用于神经系统疾病的研究，如阿尔茨海默病 (AD)。

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1,4-Naphthoquinone-NH-C2-NH-Trolox

1,4-Naphthoquinone-NH-C2-NH-Trolox Chemical Structure

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1,4-Naphthoquinone-NH-C2-NH-Trolox 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

1,4-Naphthoquinone-NH-C2-NH-Trolox is a brain-penetrant Trolox (HY-101445)-vitamin K (HY-B2172) conjugate with neuroprotective activity. 1,4-Naphthoquinone-NH-C2-NH-Trolox can inhibit oxytosis, ferroptosis, ATP depletion and ROS production. 1,4-Naphthoquinone-NH-C2-NH-Trolox selective suppresses M1 markers expression. 1,4-Naphthoquinone-NH-C2-NH-Trolox can be used for the research of neurological disease, such as Alzheimer’s disease (AD)[1].

体外研究
(In Vitro)

1,4-Naphthoquinone-NH-C2-NH-Trolox (Compound 16e) 具有强效且相当的自由基清除活性，其 EC50 值为 15.4 μM[1]。
1,4-Naphthoquinone-NH-C2-NH-Trolox (0.38-25 μM, 24 h) 可抑制 HT22 海马神经细胞中的氧化死亡、铁死亡和 ATP 耗竭[1]。
1,4-Naphthoquinone-NH-C2-NH-Trolox (0.4 μM, 8 h) 可减少 HT22 细胞中的活性氧生成[1]。
1,4-Naphthoquinone-NH-C2-NH-Trolox (0.5-2.5 μM, 24 h) 可选择性抑制 HT22 细胞中的 M1 标志物[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

1,4-Naphthoquinone-NH-C2-NH-Trolox 相关抗体:

Western Blot Analysis[1]

Cell Line: HT22 cells
Concentration: 0.5, 1 and 2.5 μM
Incubation Time: 24 h
Result: Dose-dependently suppressed nitrite accumulation and IL-1β release.
Attenuated LPS-induced iNOS protein upregulation.
Did not modulate expression of the M2 markers TREM2 or TGFβ2.
体内研究
(In Vivo)

1,4-Naphthoquinone-NH-C2-NH-Trolox (Compound 16e) (0.1 mg/kg，腹腔注射，每日一次，连续 7 天) 可改善 Aβ25-35 (HY-P0128) 诱导的阿尔茨海默病小鼠的认知缺陷[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Aβ25-35 (HY-P0128)-induced acuteAlzheimer’s disease (AD) mice models[1]
Dosage: 0.1 mg/kg
Administration: Intraperitoneally injection, daily for 7 days
Result: Significantly ameliorated Aβ25-35-induced working memory deficits.
Did not ameliorate Aβ25-35-induced long-term memory deficits.
分子量

448.51

Formula

C26H28N2O5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

1,4-Naphthoquinone-NH-C2-NH-Trolox 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1,4-Naphthoquinone-NH-C2-NH-TroloxFerroptosisReactive Oxygen Species (ROS)Troloxvitamin KOxytosisATPROSHT-22Alzheimer’s diseaseInhibitorinhibitorinhibit

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