1. Metabolic Enzyme/Protease
  2. Drug Metabolite
  3. 1'-Hydroxymidazolam

1'-Hydroxymidazolam 

目录号: HY-118645 纯度: >98.0%
产品使用指南

1'-Hydroxymidazolam 是 Midazolam 的主要活性代谢产物,并且是一种神经元抑制剂。1'-Hydroxymidazolam 能够抑制神经元活性并增加 Midazolam 的作用。

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1'-Hydroxymidazolam Chemical Structure

1'-Hydroxymidazolam Chemical Structure

CAS No. : 59468-90-5

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Description

1'-Hydroxymidazolam is a primary active metabolite of Midazolam, and it is a neuronal depressant agent. 1'-Hydroxymidazolam could inhibit neuronal activity add to the effects of Midazolam[1][2].

In Vitro

1'-Hydroxymidazolam (5 nM-1 µM) induces a significant inhibition of the action potential firing rate at concentrations of 100 nM or higher and causes a steady increase in the depression of network activity with increasing concentrations of up to 1 µM in neocortical slice cultures from wild-type mice[2].

Molecular Weight

341.77

Formula

C₁₈H₁₃ClFN₃O

CAS No.

59468-90-5

中文名称

1-羟基咪达唑仑

SMILES

OCC1=NC=C2N1C3=CC=C(Cl)C=C3C(C4=CC=CC=C4F)=NC2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

References

Purity: >98.0%

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Keywords:

1'-HydroxymidazolamDrug MetabolitemetaboliteMidazolamneuronaldepressantInhibitorinhibitorinhibit

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产品名称:
1'-Hydroxymidazolam
目录号:
HY-118645
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