1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. Potassium Channel
    GABA Receptor
  3. 12,14-Dichlorodehydroabietic acid

12,14-Dichlorodehydroabietic acid 

目录号: HY-133596
产品使用指南

12,14-Dichlorodehydroabietic acid,一种氯化树脂酸,是有效的 Ca2+-activated K+ (BK) 通道开启剂。12,14-Dichlorodehydroabietic acid 阻止哺乳动物大脑中 GABA 依赖的氯离子进入,并作为非竞争性 GABAA 拮抗剂起作用。12,14-Dichlorodehydroabietic acid 可增加细胞内游离 Ca2+ 的含量,并刺激递质释放。

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12,14-Dichlorodehydroabietic acid Chemical Structure

12,14-Dichlorodehydroabietic acid Chemical Structure

CAS No. : 65281-77-8

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Description

12,14-Dichlorodehydroabietic acid, a chlorinated resin acid, is a potent Ca2+-activated K+ (BK) channel opener. 12,14-Dichlorodehydroabietic acid blocks GABA-dependent chloride entry in mammalian brain and operates as a non-competitive GABAA antagonist. 12,14-Dichlorodehydroabietic acid increases cytosolic free Ca2+ and stimulates transmitter release[1][2].

IC50 & Target

Ca2+-activated K+ (BK) channel[2]
GABAA[1]

Molecular Weight

369.33

Formula

C₂₀H₂₆Cl₂O₂

CAS No.

65281-77-8

中文名称

二氯脱氢松香酸

SMILES

O=C([C@]1(C)CCC[C@]2(C)C3=C(CC[C@@]12[H])C(Cl)=C(C(C)C)C(Cl)=C3)O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

12,14-Dichlorodehydroabietic acidPotassium ChannelGABA ReceptorKcsAGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorChlorinatedresinacidCa2+transmitterGABAABKα,Inhibitorinhibitorinhibit

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产品名称:
12,14-Dichlorodehydroabietic acid
目录号:
HY-133596
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