2. Membrane Transporter/Ion Channel
  3. Apical Sodium-Dependent Bile Acid Transporter
  4. 264W94

264W94 是有效的回肠胆汁酸转运蛋白 (IBAT) 抑制剂，是新型降胆固醇药。264W94 具有 CYP7A1 诱导作用和抗血脂作用。

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264W94 Chemical Structure

264W94 Chemical Structure

CAS No. : 178961-24-5

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264W94 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

264W94 is a potent ileal bile acid transporter (IBAT) inhibitor and a new cholesterol lowering agent. 264W94 has CYP7A1 induction, and antilipemic action[1].

IC50 & Target

IBAT[1]
体外研究
(In Vitro)

264W94 (0, 0.1, 0.25, 0.5 μM) inhibits human IBAT-specific transport of 5 μM TC by 14% to 75% in a concentration-dependent manner with IC50 of 0.25 μM in CHO-hIBAT cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

264W94 相关抗体:
体内研究
(In Vivo)

264W94 (orally; 0.03-1.0 mg/kg; twice a day for 3.5 days) dose-dependently attenuates diet-induced increases in serum LDL+VLDL-C, as well as the decrease in HDL-C[1].
264W94 (orally; 0.003, 0.01, 0.03, 0.1 mg/kg; twice a day for 2 days) increases fecal excretion of 75SeHCAT in a dose-dependent manner[1].
264W94 (0.001, 0.01, 0.1, 1, and 10 mg/kg; twice a day for 2 weeks) reduces dose-dependently plasma glucose in male ZDF (ZDF/GmiCrl-fa/fa) rats. Treatment of 264W94 prevents the decline of insulin dose-dependently without an increase in proinsulin levels[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague Dawley rats (CD, Charles River, 270-310 gm)[1]
Dosage: 0.03, 0.1, 0.3, 1.0 mg/kg
Administration: Orally; twice a day (9:00 am and 3:30 pm) for 3.5 days
Result: Dose-dependently attenuated diet-induced increases in serum LDL+VLDL-C, as well as the decrease in HDL-C.
分子量

417.56

Formula

C23H31NO4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

264W94 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

264W94178961-24-5Apical Sodium-Dependent Bile Acid TransporterASBTIleal Bile Acid TransporterIBATSLC10A2Inhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-19264
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