2. Metabolic Enzyme/Protease NF-κB Immunology/Inflammation
  3. Endogenous Metabolite Reactive Oxygen Species (ROS)
  4. 3′-Oxolutein

3′-Oxolutein  (Synonyms: 3'-Dehydrolutein; Philosamiaxanthin)

目录号: HY-W743769
产品使用指南 技术支持

3′-Oxolutein 是膳食叶黄素的一种代谢物，是一种抗炎剂和抗氧化剂。3′-Oxolutein 可减轻谷氨酸在 SH-SY5Y 细胞中诱导的活性氧 (ROS) 生成及促炎细胞因子分泌的作用。3'-Oxolutein 能降低谷氨酸诱导的铁含量并提高硫醇水平。3′-Oxolutein 可用于炎症相关研究。

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3′-Oxolutein

3′-Oxolutein Chemical Structure

CAS No. : 23984-55-6

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3′-Oxolutein 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

3′-Oxolutein, a metabolite of dietary lutein, is an anti-inflammatory agent and antioxidant, 3′-Oxolutein mitigates the effects of glutamate-induced ROS production and proinflammatory cytokine secretions in SH-SY5Y cells. 3'-Oxolutein reduces glutamate-induced iron content and increases thiol levels. 3′-Oxolutein can be used for the study of inflammation[1].

体外研究
(In Vitro)

3'-Oxolutein (10 ng/μL, 10-30 min) 显著降低 SH-SY5Y 细胞中谷氨酸诱导的活性氧 (ROS) 生成[1].
3'-Oxolutein (10 ng/μL, 24-72 h) 在 48 h 时提高小分子抗氧化剂水平，但无法改变谷氨酸处理的 SH-SY5Y 细胞的总抗氧化能力 (TAC) 水平[1].
3'-Oxolutein (10 ng/μL, 24-72 h) 单独处理不改变超氧化物歧化酶 (SOD) 活性，也不能抑制谷氨酸处理的 SH-SY5Y 细胞中 SOD 活性的下降[1].
3'-Oxolutein (10 ng/μL, 24-72 h)可降低谷氨酸诱导的 SH-SY5Y 细胞中的铁含量[1].
3'-Oxolutein (10 ng/μL, 24-72 h) 可降低谷氨酸诱导的 SH-SY5Y 细胞中 ALOX5、ALOX15 和 ACSL4 基因的 mRNA 表达[1].
3'-Oxolutein (10 ng/μL, 24-72 h) 在 48 h 和 72 h 时显著提高硫醇水平[1].
3'-Oxolutein (10 ng/μL, 24-72 h) 对 SH-SY5Y 细胞中 IL-6 的分泌无显著影响，可降低谷氨酸诱导的 IL-8 分泌，并降低 TNFα 水平[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

3′-Oxolutein 相关抗体:

Real Time qPCR[1]

Cell Line: SH-SY5Y cells
Concentration: 10 ng/μL
Incubation Time: 24, 48, 72 h
Result: Reduced relative mRNA expressions of ALOX5, ALOX15, and ACSL4 genes in OG1 and OG5 treatments compared to glutamate-treated SH-SY5Y cells.
分子量

566.86

Formula

C40H54O2
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

3′-Oxolutein 相关分类

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Keywords:

3′-Oxolutein23984-55-63'-Dehydrolutein PhilosamiaxanthinEndogenous MetaboliteReactive Oxygen Species (ROS)inflammationSH-SY5Y cells,3’-oxoluteinoxidative stressglutamateneuronInhibitorinhibitorinhibit

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