2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor
  3. ROR
  4. 7ß,27-Dihydroxycholesterol

7ß,27-Dihydroxycholesterol  (Synonyms: 7β, 27-OHC)

目录号: HY-138115 纯度: ≥99.0%
COA 产品使用指南

摩尔计算器

7ß,27-Dihydroxycholesterol (7β, 27-OHC) 是一种强效和选择性的 RORγt 激动剂 (Ki=120 nM)。7ß,27-Dihydroxycholesterol 能够促进小鼠和人的 CD4+ Th17 细胞的分化。7ß,27-Dihydroxycholesterol 也会增加依赖于 CYP27A1 的 IL-17 的产生。

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7ß,27-Dihydroxycholesterol Chemical Structure

7ß,27-Dihydroxycholesterol Chemical Structure

CAS No. : 240129-43-5

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1 mg ￥7450
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7ß,27-Dihydroxycholesterol 相关抗体

Top Publications Citing Use of Products

查看 ROR 亚型特异性产品:

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RORγ RORα RORβ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

7ß,27-Dihydroxycholesterol (7β, 27-OHC) is a potent and selective activator of RORγt (Ki=120 nM). 7ß,27-Dihydroxycholesterol promotes the differentiation of mouse and human CD4+ Th17 cells. 7ß,27-Dihydroxycholesterol also increases the production of IL-17 depended on CYP27A1[1].

IC50 & Target[1]

RORγt

120 nM (Ki)

体外研究
(In Vitro)

7ß,27-Dihydroxycholesterol (0.3 μM 或 6 μM; 2 h) 在体外分别诱导人类和小鼠 Th17 细胞产生 IL-17[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

7ß,27-Dihydroxycholesterol 相关抗体:
体内研究
(In Vivo)

7ß,27-Dihydroxycholesterol (60 mg/kg;皮下注射; 每天 2 次，共 3 天) 在体内诱导小鼠产生 IL-17[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

418.65

Formula

C27H46O3
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: ≥99.0%

COA (264 KB)

产品使用指南 (1538 KB)
参考文献

7ß,27-Dihydroxycholesterol 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

7ß,27-Dihydroxycholesterol240129-43-57β, 27-OHCRORRAR-related orphan receptorInhibitorinhibitorinhibit

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