2. Apoptosis
  3. Ferroptosis
  4. CGP 65015

CGP 65015 是一种可口服的铁螯合剂，可以清除铁沉积。

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CGP 65015 Chemical Structure

CGP 65015 Chemical Structure

CAS No. : 189564-33-8

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     可免费申领三个不同产品的试用装。

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规格 是否有货
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CGP 65015 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

CGP 65015 is an oral iron chelator, which can mobilize iron deposits.

体外研究
(In Vitro)

CGP 65015 is an oral iron chelator[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CGP 65015 相关抗体:
体内研究
(In Vivo)

CGP65015 (150 μmol IBE/kg p.o. on d0) dramatically increases the urinary and faecal iron clearance, and still enhances iron elimination during the second post-treatment day in iron-overloaded marmosets[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

261.27

Formula

C14H15NO4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献
Animal Administration
[1]

Marmosets[1]
To approximate the iron status of thalassaemic patients in the marmosets, the animals are iron-overloaded by three i.p. injections of iron (III) hydroxide polyisomaltose at 14-d intervals (200 mg/kg twice and 100 mg/kg at the third injection). Prior to the first exposure to an iron chelator (CGP 65015), the marmosets are rested for at least 8 weeks in order to allow definite distribution of the injected iron into all storage compartments. CGP 65015 is dispersed in 40% aqueous Cremophor RH 40 for oral administration of 150 μmol IBE/kg. All dosages are expressed in terms of 'iron binding equivalents' (IBE) which take into account the stoichiometry of the chelator in the iron complex, i.e. 150 μmol IBE correspond to 150, 300 and 450 μmol of a mono-, bi- and tridentate chelator respectively. The standard dose is 150 μmol iron binding equivalents (IBE) per kg body weight. The applied volume is 5 mL/kg body weight[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

CGP 65015 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CGP 65015189564-33-8CGP65015CGP-65015FerroptosisInhibitorinhibitorinhibit

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目录号：
HY-100329
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