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Dimetacrine  (Synonyms: 二甲他林; Dimethacrine)

目录号: HY-B2075
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Dimetacrine 是一种有用的抗抑作用，可用于各种类型的抑郁症的研究。

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Dimetacrine Chemical Structure

Dimetacrine Chemical Structure

CAS No. : 4757-55-5

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Dimetacrine 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Dimetacrine is a useful antidepressant effect, and can be used for the research of various types of depression.

体内研究
(In Vivo)

Dimetacrine is a useful antidepressant which can be used for the treatment of various types of depression. Dimetacrine in the highest concentration, 10 μM, decreases the contractile force to 36.5±9.1%. Dimetacrine, 0.3 μM, causes no statistically significant decline in contractile force from the controls. Tachycardia is observed after the administration of Dimetacrine, 1 to 3 mg/kg i.v., and the maximum response is obtained in dose of 3 mg/kg i.v.. The administration of Dimetacrine, 30 mg/kg i.v., causes an abrupt fall in blood pressure with tachycardia or bradycardia followed by cardiac arrest. Respiratory rate increases 40 min after the onset of infusion of Dimetacrine. Arterial blood pressure falls 50 min after the onset of infusion of Dimetacrine[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

294.43

Formula

C20H26N2
CAS 号
中文名称

二甲他林
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献
Animal Administration
[1]

Adult male mongrel dogs weighing 8 to 13 kg are used and anesthetized with sodium pentobarbital, 35 mg/kg i.v. Respiratory movement is measured by an accordion-type pneumograph placed around the thoraco-abdominal region and a pressure transducer. For the experiments on single i.v. injections, the increasing doses of Dimetacrine, 0.1, 0.3, 1, 3, 10 and 30 mg/kg i.v., until cardiac arrest occurs, are given into the cannulated left cephalic vein and are flushed with 1 mL of physiological saline. The changes in arterial blood pressure and heart rate caused by each dose are estimated for IMP, AMT and Dimetacrine[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

Dimetacrine 相关分类

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Keywords:

Dimetacrine4757-55-5Dimethacrine二甲他林OthersInhibitorinhibitorinhibit

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