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PF-02575799 

目录号: HY-100333
产品使用指南

MTP-IN-1是微粒体甘油三酯转移蛋白 (microsomal triglyceride transfer protein (MTP)) 抑制剂,IC50 值为0.77±0.29 nM。

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PF-02575799 Chemical Structure

PF-02575799 Chemical Structure

CAS No. : 863491-70-7

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  • 生物活性

  • 实验参考方法

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  • 参考文献

生物活性

PF-02575799 is a microsomal triglyceride transfer protein (MTP) inhibitor with an IC50 of 0.77±0.29 nM.

IC50 & Target

IC50: 0.77±0.29 nM (MTP)[1]

体外研究
(In Vitro)

PF-02575799 is compound 13 from the reference[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

PF-02575799 produces appreciable triglyceride effects at its minimally effective dose (10 mg/kg). PF-02575799 significant increase alanine transaminase at 100 mg/kg[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

680.77

Formula

C42H37FN4O4

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
Animal Administration
[1]

Rats[1]

Spray-dried dispersions formulated PF-02575799 is tested in a seven-day rat model. Food intake, body weight, liver TG, as well as serum alanine transaminase (ALT) are measured. In the definitive study, dose effect relationships are examined (PF-02575799 1, 3, 10, 30 and 100 mg/kg q.d.) and systemic exposures are measured[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

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产品名称:
PF-02575799
目录号:
HY-100333
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