1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Mitochondrial Metabolism

Mitochondrial Metabolism

Mitochondria use multiple carbon fuels to produce ATP and metabolites, including pyruvate, which is generated from glycolysis; amino acids such as glutamine; and fatty acids. These carbon fuels feed into the TCA cycle in the mitochondrial matrix to generate the reducing equivalents NADH and FADH2, which deliver their electrons to the electron transport chain. Mitochondria are complex organelles that play an important role in many facets of cellular function, from metabolism to immune regulation and cell death. Mitochondria are actively involved in a wide variety of cellular processes and molecular interactions, such as calcium buffering, lipid flux, and intracellular signaling. It is increasingly recognized that mitochondrial dysfunction is a hallmark of many diseases such as obesity/diabetes, cancer, cardiovascular and neurodegenerative diseases. Mitochondrial metabolism is a key determinant of tumor progression by impacting on functions such as epithelial-to-mesenchymal transition. Mitochondrial metabolism and derived oncometabolites shape the epigenetic landscape to alter aggressiveness features of cancer cells. Changes in mitochondrial metabolism are relevant for the survival of tumors in response to therapy.

Mitochondrial Metabolism 相关产品 (38):

Cat. No. Product Name Effect Purity
  • HY-100941
    CCCP Inhibitor 99.83%
    CCCP 是氧化磷酸化解偶联剂。CCCP 诱导 PINK1 激活,促进 Parkin 在 Ser65 位点磷酸化。
  • HY-B1756
    Rotenone Inhibitor 98.12%
    Rotenone 是线粒体电子传递链复合物I抑制剂。 Rotenone 通过促进线粒体活性氧的产生来诱导细胞凋亡。
  • HY-100410
    FCCP 99.39%
    FCCP 是线粒体中氧化磷酸化的解偶联剂。FCCP 诱导 PINK1 激活,促进 Parkin 在 Ser65 位点磷酸化。
  • HY-13653
    (-)-Epigallocatechin Gallate Activator 99.91%
    (-)-Epigallocatechin Gallate是一种茶类黄酮,具有强大的抗氧化,抗炎和抗癌作用。报道显示(-)-Epigallocatechin Gallate可抑制 EGFR 信号传导,从而发挥抗癌作用。(-)-Epigallocatechin Gallate (EGCG) 是谷氨酸脱氢酶 1/2 (GDH1/2GLUD1/2) 抑制剂。(-)-Epigallocatechin Gallate 通过激活细胞色素c氧化酶来诱导氧化磷酸化。
  • HY-15475
    UK-5099 Inhibitor 99.70%
    UK-5099 (PF-1005023) 是线粒体丙酮酸转运蛋白 (MPC) 的有效抑制剂, 抑制丙酮酸依赖性O2消耗的 IC50 值为50 nM。
  • HY-N6790
    Nonactin >99.0%
    Nonactin 来源于 Streptomyces griseus, 是一种抗生素,作为 K+NH4+ 载体。Nonactin 是一种氧化磷酸化解偶联剂。Nonactin 选择性诱导含突变 β-catenin 的细胞凋亡。Nonactin 抑制内源性 HSP60 表面表达。
  • HY-N7063
    Nerol 是橙花油的一种成分, Nerol 通过增强 Ca2+ROS 来触发线粒体功能障碍并诱导凋亡。具有抗真菌活性。
  • HY-N6882
    Genistein 8-c-glucoside Activator 99.40%
    Genistein 8-c-glucoside (G8CG) 是从 Lupinus luteus L 花中分离的一种天然葡萄糖苷。Genistein 8-c-glucoside 诱导线粒体膜去极化并诱导细胞凋亡 (apoptosis)。
  • HY-P0025
    NIM811 Inhibitor 99.55%
    NIM811 ((Melle-4)cyclosporin; SDZ NIM811) 是一种有效的且生物可利用的线粒体渗透转换亲环蛋白双抑制剂,对丙型肝炎病毒 (HCV) 具有很强的体外活性。
  • HY-112879
    Mito-TEMPO 98.05%
    Mito-TEMPO 是一种线粒体靶向超氧化物歧化酶,有着清除超氧化物和烷基自由基的能力。
  • HY-P0125
    Elamipretide Inhibitor 99.89%
    Elamipretide (MTP-131;RX-31;SS-31) 是一种靶向作用于线粒体内膜的多肽,是心磷脂过氧化物酶 (cardiolipin peroxidase) 抑制剂。
  • HY-N0018
    Daidzin Inhibitor 99.53%
  • HY-14771A
    Imeglimin hydrochloride Activator >98.0%
    Imeglimin hydrochloride 是第一个诱导线粒体磷脂 (mitochondrial phospholipid) 成分增加的抗糖尿病化合物,有助于改善肝脏线粒体功能。
  • HY-111536
    Mitochonic acid 5 Modulator 99.31%
    Mitochonic acid 5 与线粒体结合,并改善肾小管和心肌细胞损伤。Mitochonic acid 5 调节线粒体 ATP 合成。
  • HY-P0125A
    Elamipretide TFA Inhibitor 99.81%
    Elamipretide TFA (MTP-131 TFA; RX-31 TFA; SS-31 TFA) 是一种靶向作用于线粒体内膜的多肽,是心磷脂过氧化物酶 (cardiolipin peroxidase) 抑制剂。
  • HY-B0486
    Lonidamine Inhibitor
    Lonidamine (AF-1890),一种抗肿瘤药物,是己糖激酶线粒体丙酮酸载体 (分离的大鼠肝线粒体中的 Ki 2.5 μM) 和质膜单羧酸转运蛋白抑制剂,同时也抑制线粒体复合物 II。
  • HY-N0492
    α-Lipoic Acid 98.03%
    α-Lipoic Acid 是一种抗氧化剂,是线粒体酶复合物的重要辅助因子。α-Lipoic Acid 可抑制 NF-κB 依赖性的 HIV-1 LTR活化。
  • HY-18733
    Lipoic acid 99.59%
    Lipoic acid ((R)-(+)-α-Lipoic acid) 是一种抗氧化剂,是线粒体酶复合物的重要辅助因子。(R)-(+)-α-Lipoic acid 比外消旋 Lipoic acid 更有效。
  • HY-14796
    Olesoxime Inhibitor 99.70%
    Olesoxime (TRO 19622) 是一种靶向线粒体的神经保护性试剂,促进细胞存活,EC50 为 3.2±0.2 µM。
  • HY-100852
    ER-000444793 Inhibitor >98.0%
    ER-000444793 是有效的线粒体通透性转换孔 (mPTP) 开放抑制剂。ER-000444793 抑制 mPTP, IC50 为 2.8 μM。
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