1. Signaling Pathways
  2. Cell Cycle/DNA Damage
  3. DNA Alkylator/Crosslinker

DNA Alkylator/Crosslinker

DNA alkylator/crosslinker is a molecule that alkylates DNA or can cross link with DNA. DNA alkylator/crosslinker can have mutagenic, pharmaceutical, or other effects. Alkylation is the transfer of an alkyl group from one molecule to another. The alkyl group may be transferred as an alkyl carbocation, a free radical, a carbanion or a carbene. Alkylating agents are widely used in chemistry because the alkyl group is probably the most common group encountered in organic molecules. Selective alkylation, or adding parts to the chain with the desired functional groups, is used, especially if there is no commonly available biological precursor. Alkylation with only one carbon is termed methylation. In medicine, alkylation of DNA is used in chemotherapy to damage the DNA of cancer cells. Alkylation is accomplished with the class of drugs called alkylating antineoplastic agents. Crosslinking of DNA occurs when various exogenous or endogenous agents react with two different positions in the DNA. This can either occur in the same strand (intrastrand crosslink) or in the opposite strands of the DNA (interstrand crosslink). Crosslinks also occur between DNA and protein. DNA replication is blocked by crosslinks, which causes replication arrest and cell death if the crosslink is not repaired. The RAD51 family plays a role in repair.

DNA Alkylator/Crosslinker 相关产品 (44):

Cat. No. Product Name Effect Purity
  • HY-17394
    Cisplatin >99.0%
    Cisplatin 是一种抗肿瘤化疗药物,它与 DNA 交联引起癌细胞中DNA损伤。
  • HY-13316
    Mitomycin C 99.45%
    Mitomycin C是一种抗肿瘤药物和抗生素,可有效的抑制DNA合成 (DNA synthesis)。Mitomycin C 是一种 DNA 交联剂,诱导 DNA 损伤。
  • HY-17371
    Oxaliplatin 99.86%
    Oxaliplatin 是一种 DNA 合成 抑制剂。Oxaliplatin 会导致 DNA 交联损伤,阻止 DNA 复制和转录并导致细胞死亡。Oxaliplatin 以时间依赖方式抑制人黑色素瘤细胞系 C32 和 G361,IC50 值分别为 0.98 μM 和 0.14 μM。
  • HY-17364
    Temozolomide 99.96%
    Temozolomide (NSC 362856; CCRG 81045) 是可口服的用于治疗某些脑癌的DNA烷基化剂。
  • HY-17420
    Cyclophosphamide >98.0%
    Cyclophosphamide 是一种合成的 DNA Alkylator,在化学上与氮芥类有关,具有抗肿瘤及免疫抑制活性。
  • HY-128612
    Methylnitronitrosoguanidine >98.0%
    Methylnitronitrosoguanidine (MNNG) 是一种烷化剂 (alkylating agent),具有毒性和致突变作用。
  • HY-129356
    Seco-Duocarmycin SA
    Seco-Duocarmycin SA 是一种高效的 DNA 烷化剂 (DNA alkylator),可作用做抗体-药物偶联物 (ADC) 的毒素部分。
  • HY-128881
    (+)-CBI-CDPI2
    (+)-CBI-CDPI2 是 CC-1065 功能增强的一种类似物。(+)-CBI-CDPI1 是一种 DNA 烷化剂。(+)-CBI-CDPI2 可用作抗体-药物偶联物 (ADCs) 中的毒素分子。
  • HY-13753
    Streptozocin 99.58%
    Streptozocin 是一种抗生素,可使 DNA 甲基化 (DNA-methylating) 。Streptozocin 引起肝脏,肾脏及胰腺 DNA 甲基化,但脑 DNA 中没有甲基化。
  • HY-17393
    Carboplatin 99.93%
    Carboplatin (NSC 241240) 是一种 DNA 合成 抑制剂,其与 DNA 结合,抑制复制和转录并诱导细胞死亡。Carboplatin (NSC 241240) 是顺铂的衍生物,是一种有效的抗癌剂。
  • HY-19609
    Calicheamicin 98.44%
    Calicheamicin 是一种肿瘤抗生素,也是有效的细胞毒性试剂,可引起DNA双链断裂。Calicheamicin 抑制 DNA 合成。
  • HY-17575
    Melphalan >98.0%
    Melphalan 是一种有效的 DNA 烷化剂 (DNA alkylator),具有抗肿瘤活性。
  • HY-B0245
    Busulfan >98.0%
    Busulfan是一种有效的烷化剂,对骨髓具有选择性免疫抑制作用。
  • HY-17419
    Ifosfamide >98.0%
    Ifosfamide 是一种烷化剂 (DNA alkylator),具有广谱的抗肿瘤作用。
  • HY-17420A
    Cyclophosphamide hydrate >98.0%
    Cyclophosphamide hydrate 是一种合成的 DNA Alkylator,在化学上与氮芥类有关,具有抗肿瘤及免疫抑制活性。
  • HY-B0077
    Bendamustine hydrochloride >98.0%
    Bendamustine hydrochloride 是一种 DNA 交联剂 (DNA crosslinker),能够导致 DNA 断裂,具有烷基化和抗代谢物的作用。
  • HY-13585
    Carmustine 99.85%
    Carmustine 是一种抗肿瘤化疗剂,为 DNARNA 的烷化剂 (alkylator)。
  • HY-13424
    RITA 99.57%
    RITA 是一种有效的 p53-HDM-2 相互作用抑制剂,可与 p53dN 结合,Kd 值为 1.5 nM,同时能够诱导 DNA-DNA 交联。
  • HY-13733
    Procarbazine Hydrochloride
    Procarbazine Hydrochloride 是一种烷化剂 (alkylator),具有抗肿瘤的作用。
  • HY-13669
    Lomustine 99.91%
    Lomustine (CCNU; NSC 79037) 是一种 DNA 烷化剂 (DNA alkylator),具有抗肿瘤活性。
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