1. Signaling Pathways
  2. Epigenetics
  3. DNA Methyltransferase

DNA Methyltransferase

DNA methylation, defined by the addition of a methyl group to adenine or cytosine bases in DNA catalyzed by DNA methyltransferases (MTases), is one of the most studied post-replicative DNA modification mechanism in bacteria. The three forms of nucleotide methylation identified to date are: N6-methyladenine(m6A), N4-methylcytosine (m4C), and 5-methylcytosine (m5C).

DNA methylation, one type of epigenetic modification, represses gene expression. DNA methylation is caused primarily by a family of DNA methyltransferases (DNMTs) including DNMT1, DNMT3a and DNMT3b. Conventionally, DNMT1 acts as the primary maintenance methyltransferase to keep the methylation of DNA that is already established at the genome, whereas DNMT3a and DNMT3b are classified asde novo methyltransferases to reversibly methylate unmethylated DNA. DNA methylation represses gene transcription through several mechanisms including physically blocking the binding of transcription factors and/or functioning as docking sites for transcriptional repressors/corepressors.

In epigenetic transcriptional regulation, which is important for embryonic development, DNA-methylation patterns are determined by de novo methylation by the DNA methyltransferases Dnmt3a and Dnmt3b in the embryo.

DNA methylation on the cytosine of CpGdinucleotides in gene promoter regions is associated with silencing gene expression. Of the DNA methyltransferases, only DNA methyltransferase 3a (DNMT3a) and 3b (DNMT3b) are capable of adding de novo CpG methylation marks and thus may dynamically regulate gene silencing.

DNA Methyltransferase Isoform Specific Products:

  • DNA Methyltransferase

  • DNMT1

  • DNMT3

  • MGMT

DNA Methyltransferase 相关产品 (17):

Cat. No. Product Name Effect Purity
  • HY-A0004
    Decitabine Inhibitor 99.99%
    Decitabine (NSC 127716) 是一种DNA甲基转移酶抑制剂,通常用于治疗骨髓增生异常综合征(MDS) 和急性髓性白血病 (AML)。
  • HY-10586
    5-Azacytidine Inhibitor 99.97%
    5-Azacytidine是胞苷的核苷类似物,其通过捕获 DNA甲基转移酶 特异性地抑制DNA甲基化。
  • HY-13962
    SGI-1027 Inhibitor 99.92%
    SGI-1027 是 DNA 甲基转移酶 (DNMT) 抑制剂,对以 poly(dI-dC) 为底物的 DNMT3B,DNMT3A 和 DNMT1 的 IC50 值分别为 7.5 μM,8 μM 和 12.5 μM。
  • HY-15229
    Guadecitabine sodium Inhibitor 98.06%
    Guadecitabine sodium (SGI-110 sodium; S-110 sodium) 是由5-Aza-CdR和脱氧鸟苷组成的二核苷酸,是有效的DNA甲基化 (DNA methylation inhibitor) 抑制剂。
  • HY-13642
    RG108 Inhibitor 99.75%
    RG108 是一种非核苷的 DNA 甲基转移酶 (DNA methyltransferase) 抑制剂,IC50 值为 115 nM。
  • HY-W012078
    5-Methyl-2'-deoxycytidine 98.15%
    5-Methyl-2'-deoxycytidine 在单链 DNA 中可发生顺式作用,使 DNA 从头甲基化。
  • HY-13420
    Zebularine Inhibitor 99.92%
    Zebularine (NSC309132; 4-Deoxyuridine)是DNA甲基转移酶抑制剂;也可抑制胞苷脱氨酶Ki值为0.95 μM。
  • HY-13668
    Lomeguatrib Inhibitor
    Lomeguatrib 是一种有效的 MGMT 抑制剂,在非细胞体系和 MCF-7 细胞体系中,IC50 值分别为 9 nM 和 ∼6 nM。
  • HY-B2230
    Hinokitiol Inhibitor 99.28%
    Hinokitiol 是从日本扁柏中分离到的挥发油成分,能够降低 Nrf2 的表达,减少 DNMT1 和 UHRF1 的 mRNA 和蛋白的表达,具有抗感染、抗氧化及抗肿瘤等活性。
  • HY-13542
    Guadecitabine Inhibitor 98.00%
    Guadecitabine (SGI-110) 是 DNA 甲基转移酶 (DNMT) 的抑制剂。
  • HY-B2194
    γ-Oryzanol Inhibitor
    γ-Oryzanol 有效抑制小鼠纹状体中的 DNA 甲基转移酶 (DNMTs)。 抑制 DNMT1DNMT3aIC50 分别为 3.2 μM 和 22.3 μM。
  • HY-12747
    DC_517 Inhibitor 99.66%
    DC_517 是一种 DNMT1 抑制剂,IC50Kd 值分别为 1.7 μM 和 0.91 μM。
  • HY-117421A
    CM-579 trihydrochloride Inhibitor 98.03%
    CM-579 trihydrochloride 是一线的、可逆的,G9a 和DNA 甲基转移酶 (DNMT) 的双抑制剂,其IC50 值分别为 16 nM 和32 nM。在多种癌细胞中发挥有效活性作用。
  • HY-12746
    DC-05 Inhibitor 99.15%
    DC-05 是一种 DNMT1 抑制剂,IC50Kd 值分别为 10.3 μM 和 1.09 μM。
  • HY-117421
    CM-579 Inhibitor
    CM-579 是一线的、可逆的,G9a 和DNA 甲基转移酶 (DNMT) 的双抑制剂,其IC50 值分别为 16 nM 和32 nM。在多种癌细胞中发挥有效活性作用。
  • HY-111644
    6-Methyl-5-azacytidine Inhibitor
    6-Methyl-5-azacytidine 是一种有效的甲基转移酶抑制剂。
  • HY-13057
    Glucose-conjugated MGMT inhibitor Inhibitor
    Glucose-conjugated MGMT inhibitor 是一种有效的 MGMT 抑制剂,在细胞提取物及 HeLa S3 细胞中,IC50 值分别为 32 nM 和 10 nM。
Isoform Specific Products

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