1. Signaling Pathways
  2. Immunology/Inflammation
  3. FLAP

FLAP

FLAP (Arachidonate 5-lipoxygenase-activating protein) is a protein that in humans is encoded by the ALOX5AP gene. FLAP is necessary for the activation of 5-lipoxygenase and therefore for the production of leukotrienes. It is an integral protein within the nuclear membrane. FLAP is necessary in synthesis of leukotriene, which are lipid mediators of inflammation that is involved in respiratory and cardiovascular diseases. FLAP functions as a membrane anchor for 5-lipooxygenase and as an amine acid-bind protein. Gene polymorphisms in FLAP are suspected of playing a role in Alzheimer's disease. Leukotrienes, which need the FLAP protein to be made, have an established pathological role in allergic and respiratory diseases. Animal and human genetic evidence suggests they may also have an important role in atherosclerosis, myocardial infarction, and stroke. The structure of FLAP provides a tool for the development of novel therapies for respiratory and cardiovascular diseases and for the design of focused experiments to probe the cell biology of FLAP and its role in leukotriene biosynthesis.

FLAP 相关产品 (9):

Cat. No. Product Name Effect Purity
  • HY-14166
    MK-886 Inhibitor 99.77%
    MK-886 (L 663536) 是一种有效的,细胞可渗透的且具有口服活性的 FLAP (IC50 为 30 nM) 和白三烯生物合成 (完整白细胞和人全血中的 IC50 分别为 3 nM 和 1.1μM) 的抑制剂。MK-886 也是一种非竞争性 PPARα 拮抗剂,可以诱导细胞凋亡。
  • HY-15874
    Fiboflapon Inhibitor 98.18%
    Fiboflapon (GSK2190915; AM-803) 是一种口服有效的 5-脂氧合酶激活蛋白 (FLAP) 抑制剂,结合 FLAP 的效价为 2.9 nM,在人血中抑制 LTB4IC50 为 76 nM。
  • HY-10037
    MK591 free acid Inhibitor 99.82%
    MK591 (free acid) 是FLAP特异性抑制剂,IC50 为1.6 nM。
  • HY-15874A
    Fiboflapon sodium Inhibitor 99.08%
    Fiboflapon sodium (GSK2190915; AM-803) 是一种口服有效的 5-脂氧合酶激活蛋白 (FLAP) 抑制剂,结合 FLAP 的效价为 2.9 nM,在人血中抑制 LTB4IC50 为 76 nM。
  • HY-50714
    Quiflapon sodium Inhibitor 99.91%
    Quiflapon sodium (MK591) 是选择性的,特异性的 FLAP 抑制剂。
  • HY-14165
    Veliflapon Inhibitor >99.0%
    Veliflapon (BAY X 1005; DG-031) 是一种具有口服活性的,选择性的 5-脂氧合酶激活蛋白 (FLAP) 抑制剂。Veliflapon 也是白三烯 B4C4 合成的抑制剂。
  • HY-12995A
    (S)-BI 665915 Inhibitor
    (S)-BI 665915 是一种口服有效的,含恶二唑的 5-脂氧合酶激活蛋白 (FLAP) 抑制剂,与 FLAP 结合的 IC50 为 1.7 nM。(S)-BI 665915 抑制人全血中 FLAP 功能,IC50 为 45 nM。(S)-BI 665915 展示了极好的跨物种药物代谢和药代动力学 (DMPK) 谱以及对 LTB4 产生的剂量依赖性抑制。
  • HY-14460
    AM679 Inhibitor 99.98%
    AM679是高活性FLAP抑制剂,对FLAP结合/hLA/hWB的IC50分别为2.2 nM/0.6 nM/154 nM。
  • HY-14163
    AM 103 Inhibitor
    AM 103 是具有选择性的,有效的 FLAP 抑制剂,IC50 值为 4.2 nM。
Isoform Specific Products

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