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  3. MMV390048

MMV390048 

目录号: HY-106005
产品使用指南

MMV390048 是疟原虫 PI4K 抑制剂 (Kdapp=0.3 µM)。MMV390048 与疟原虫 PI4K 的 ATP 结合位点结合,除人 PIP4K2C 外不与其他恶性疟原虫和激酶结合,从而减轻潜在的激酶介导的安全性问题。MMV390048 是一种抗疟剂。

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MMV390048 Chemical Structure

MMV390048 Chemical Structure

CAS No. : 1314883-11-8

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Description

MMV390048 is a representative of a new chemical class of Plasmodium PI4K inhibitor (Kdapp=0.3 µM). MMV390048 binds to the ATP binding site of Plasmodium PI4K and does not bind to other P. falciparum and human kinases apart from human PIP4K2C, thus alleviating potential kinase-mediated safety concerns. MMV390048 is an antimalarial agent[1].

IC50 & Target

Kdapp: 0.3 µM (Plasmodium PI4K inhibitor)[1]

In Vitro

MMV390048 against intraerythrocytic life cycle stages of P. falciparum (NF54 drug-sensitive strain) showed a steep inhibition curve with IC50 and IC90 values of 28 and 40 nM, respectively.

Molecular Weight

393.38

Formula

C₁₈H₁₄F₃N₃O₂S

CAS No.

1314883-11-8

SMILES

NC1=NC=C(C2=CC=C(S(=O)(C)=O)C=C2)C=C1C3=CC=C(C(F)(F)F)N=C3

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
MMV390048
目录号:
HY-106005
需求量:

MMV390048

Cat. No.: HY-106005