2. Membrane Transporter/Ion Channel
  3. VDAC
  4. SW016789

SW016789 是一种针对 VDAC1 的高分泌诱导剂。SW016789 能够直接诱导 β 细胞的胰岛素分泌和钙离子内流。SW016789 能诱导瞬时性内质网应激反应（ ER 应激），但不会导致 β 细胞死亡。 SW016789 诱导的反应具有可逆性和非凋亡性特征。SW016789 可用于研究2型糖尿病 ( T2DM ) 中的 β 细胞功能障碍。

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SW016789 Chemical Structure

SW016789 Chemical Structure

CAS No. : 292613-04-8

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SW016789 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SW016789 is a hypersecretion-inducer targeting VDAC1. SW016789 can induce insulin hypersecretion and Ca2+ influx in β-cells directly[1]. SW016789 induces a transient endoplasmic reticulum stress response (ER stress), but does not cause beta cell death. SW016789 has reversible and non-apoptotic characteristics. SW016789 can be used for the study of Diabetes mellitus type 2 ( T2DM ) β-cell dysfunction[2].

体外研究
(In Vitro)

SW016789 (5 μM; 0-24 h) can enhance insulin secretion stimulated by glucose within a short period of time (1-2 h), but results in loss of β cell function after longer exposure (4–24 h) in MIN6 cells[2].
SW016789 (5 μM; 24-72 h) does not affect beta cell viability or apoptosis in MIN6 cells[2].
SW016789 (5 μM; 24h) enhances nutrient-stimulated Ca2+ influx to elicit hypersecretion, VDAC1 is a pharmacological target for insulin hypersecretion in mouse MIN6 cells and human EndoC-βH1 cells [1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SW016789 相关抗体:

Cell Viability Assay[2]

Cell Line: MIN6
Concentration: 5 μM
Incubation Time: 24 h, 48 h, 72 h
Result: Did not alter relative amounts of live cells, dead cells, or the live/dead cell ratio.

Western Blot Analysis[1]

Cell Line: MIN6
Concentration: 5 μM
Incubation Time: 24 h
Result: Caused loss of function alone or in combination with eeyarestatin I (ES1) (HY-110078).

Western Blot Analysis[1]

Cell Line: Mouse MIN6; human EndoC-βH1
Concentration: 5 μM
Incubation Time: 1 h, 2 h, 4 h, 6 h, 24 h
Result: Induced the immediate-early response and did not robustly engage canonical ER stress pathways.
分子量

349.45

Formula

C20H19N3OS
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SW016789 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SW016789292613-04-8SW 016789SW-016789VDACVoltage-dependent anion channelER stressER-associated degradationcongenital hyperinsulinismdiabeteshypersecretioninsulin secretionpancreatic isletstarget identificationtranscriptomicsβ cellsInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-176745
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