1. Signaling Pathways
  2. GPCR/G Protein
  3. GLP Receptor

GLP Receptor (胰高血糖素样肽受体)

The GLP receptors contain two family members, GLP-1 receptor (GLP1R, or GLP-1R) and GLP-2 receptor (GLP2R or GLP-1R), activated by the glucagon-like peptides (GLPs). GLPs are s secreted by intestinal cells; causes insulin release; inhibits glucagon secretion, appetite, and energy intake; and delays gastric emptying because GLP receptors are located on the gut, pancreas, brainstem, hypothalamus, and vagal-afferent nerves. GLP-1 has only one known receptor, GLP1R, and regulates gut motility, appetite, islet function, and glucose homeostasis, whereas GLP-2, the agonist of GLP2R, enhances intestinal nutrient absorption. GLP-1R agonists are used to treat diabetes and obesity, and a GLP-2R agonist is approved to treat short bowel syndrome. An investigation of the actions of GLP receptor activation on gallbladder motility has demonstrated that GLP-2 receptor activation increases gallbladder volume in vivo and decreases spontaneous activity in GBSM bundles ex vivo. Like the inhibitory transmitters, which elicit their actions via an adenylate cyclase-protein kinase A-KATP channel pathway, the GLP-2 receptor signals through this same pathway.

GLP Receptor 相关产品 (9):

目录号 产品名 作用方式 纯度
  • HY-P1230
    HAEGT 99.26%
    HAEGT 是胰高血糖素样肽-1 (GLP-1) 的多肽 N-端的 1-5 残基片段,序列为 His-Ala-Glu-Gly-Thr。HAEGT 可作为竞争性底物检测人二肽基肽-IV (DPP-IV) 的底物结合位点,其 N 端 His-Ala 会被 DPP-IV 催化裂解。HAEGT 可用于糖尿病、肥胖等疾病的研究。
  • HY-108795A
    Albiglutide TFA Agonist
    Albiglutide TFA 是一种胰高血糖素样肽 GLP-1 模拟物,是长效的 GLP-1 受体激动剂。Albiglutide TFA 可显著降低糖化血红蛋白 (A1C)。Albiglutide TFA 可用于研究 2 型糖尿病 (T2D)。Albiglutide TFA 是由抗 DPP-4 的 GLP-1 二聚体与人白蛋白的基因融合产生的。
  • HY-147629
    GLP-1R agonist 16 Agonist
    GLP-1R agonist 16 (Compound 115a) 是一种 GLP-1 受体激动剂,EC50 为 0.15 nM。
  • HY-147627
    GLP-1R agonist 14 Agonist
    GLP-1R agonist 14 (Compound 14) 是一种 GLP-1 受体激动剂,对 h-GLP-1 的 EC50 为 0-20 nM。
  • HY-108795
    Albiglutide Agonist
    Albiglutide 是一种胰高血糖素样肽 -1 (GLP-1) 模拟物,是一种长效的 GLP-1 受体激动剂。Albiglutide 可显著降低糖化血红蛋白 (A1C)。Albiglutide 可用于 2 型糖尿病 (T2D) 研究。Albiglutide 是由抗 DPP-4 的 GLP-1 二聚体与人白蛋白的基因融合产生的。
  • HY-147628
    GLP-1R agonist 15 Agonist
    GLP-1R agonist 15 (Compound 101) 是一种 GLP-1 受体激动剂。
  • HY-147626
    GLP-1R agonist 13 Agonist
    GLP-1R agonist 13 (Compound 24) 是一种 GLP-1 受体激动剂。
  • HY-147623
    GLP-1R agonist 10 Agonist
    GLP-1R agonist 10 (Compound 109a) 是一种 GLP-1 激动剂,EC50 为 0.051 nM。
  • HY-147625
    GLP-1R agonist 12 Agonist
    GLP-1R agonist 12 (Compound 123) 是一种 GLP-1R 激动剂。 GLP-1R agonist 12 可用于糖尿病的研究。
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