1. GPCR/G Protein
  2. GLP Receptor GCGR
  3. Pemvidutide

Pemvidutide (ALT-801) 是一种 GLP-1R/GCGR 双重激动剂,可导致体重、肝脏脂肪和血清脂质的显著降低。Pemvidutide 可用于非酒精性脂肪性肝炎 (NASH) 和肥胖症的研究。

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Custom Peptide Synthesis

Pemvidutide Chemical Structure

Pemvidutide Chemical Structure

CAS No. : 2538014-94-5

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规格 是否有货
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Pemvidutide 的其他形式现货产品:

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Other Forms of Pemvidutide:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Pemvidutide (ALT-801) is a GLP-1R/GCGR dual agonist, shows striking reductions in body weight, liver fat and serum lipids. Pemvidutide can be used in non-alcoholic steatohepatitis (NASH) and obesity research[1].

体内研究
(In Vivo)

Pemvidutide (subcutaneous injection; 5 or 10 nmol/kg; once daily; 12 w) treatment improves NASH (nonalcoholic steatohepatitis) outcomes in vivo[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL6/J mice (with biopsy-confirmed NAS score after 29 weeks on a HFFC diet)[1]
Dosage: 5 or 10 nmol/kg
Administration: Subcutaneous injection; 5 or 10 nmol/kg; once daily; 12 weeks
Result: Lowered hepatic lipids, liver weight, biomarkers of liver injury (plasma ALT and AST), the inflammation marker galactin-3, the fibrosis marker Col1a1, and the NAS score.
分子量

3873.35

同用名

ALT-801

Formula

C182H275N39O54

CAS 号
Sequence

His-{Aib}-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Glu--{Lys(N6-(1-O-(17-Carboxyheptadecyl)-D-Glucopyranuronoyl))}-Ala-Ala-Lys-Glu-Phe-Ile-Gln-Trp-Leu-Leu-Gln-Thr-NH2 (Lactam bridge: Glu-16;Lys-20)

Sequence Shortening

H-{Aib}-QGTFTSDYSKYLDE-{Lys(N6-(1-O-(17-Carboxyheptadecyl)-D-Glucopyranuronoyl))}-AAKEFIQWLLQT-NH2 (Lactam bridge: Glu-16;Lys-20)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Pemvidutide
目录号:
HY-145632
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