1. Signaling Pathways
  2. Anti-infection
  3. VSV

VSV (水疱性口炎病毒)

Vesicular Stomatitis Virus

Vesicular stomatitis virus (VSV), which belongs to the Vesiculovirus genus of the family Rhabdoviridae, is a well studied livestock pathogen and prototypic non-segmented, negative-sense RNA virus. Although VSV is responsible for causing economically significant outbreaks of vesicular stomatitis in cattle, horses, and swine, the virus also represents a valuable research tool for molecular biologists and virologists. Many properties of VSV make it a valuable tool for molecular virology research—such as its ability to express heterologous glycoproteins and replicate to high titers—also make it an excellent vaccine platform. In addition, the apparent seroprevalence of VSV antibodies is generally low within the human population, so there is little pre-existing immunity to the vector, and because the VSV replication cycle takes place exclusively in the cytoplasm of host cells, there is no potential for viral sequences to integrate into the host genome. As a result, recombinant VSV has emerged as a viable vaccine vector, and many recombinant VSV-based vaccines have demonstrated safety and immunogenicity in multiple pre-clinical and clinical trials.

VSV 相关产品 (10):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-15273
    UNC0638 Inhibitor 99.71%
    UNC0638 选择性抑制 G9aGLP组蛋白甲基转移酶IC50 分别为15 nM 和 19 nM。UNC0638 具有抗 FMDV (口蹄疫病毒) 和抗 VSV (水疱性口炎病毒) 的活性。
    UNC0638
  • HY-13963
    ZCL278 98.46%
    ZCL278 是一种选择性的 Cdc42 调节剂,直接结合到 Cdc42,且抑制其功能,Kd 为 11.4 μM。
    ZCL278
  • HY-N2011
    Octyl gallate

    没食子酸辛酯

    Inhibitor 98.01%
    Octyl gallate (Progallin O) 广泛用作食品添加剂,具有抗菌、抗氧化作用。具有选择性、敏感性的荧光特性。Octyl gallate 对 HSV-1,水泡性口炎病毒 (VSV) 和脊髓灰质炎病毒显具有显着的抗病毒作用。
    Octyl gallate
  • HY-N2532
    Diphyllin

    二叶草素

    Inhibitor 99.90%
    Diphyllin 是一种从 Justicia procumbens 中分离出的芳基萘木脂素,是一种有效的 HIV-1 抑制剂,IC50 为 0.38 μM。Diphyllin 还具有抗水泡性口炎病毒 (VSV) 和流感病毒的活性。Diphyllin 是 V-ATPase 的抑制剂,IC50 值为 17 nM,可抑制人破骨细胞中的溶酶体酸化。Diphyllin 以 IC50 值为 50 μM 来抑制 NO 产生,并具有抗癌和抗炎活性。
    Diphyllin
  • HY-15798
    UNC2881 Inhibitor 99.79%
    UNC2881 是一种口服有效、特异性的 Mer 激酶抑制剂,可抑制稳定状态的 Mer 激酶磷酸化,IC50 为 22 nM。UNC2881 对 AxlTyro 也有抑制作用,IC50 分别为 360 nM 和 250 nM。UNC2881 可有效抑制胶原诱导的血小板聚集,可用于血栓病理研究。
    UNC2881
  • HY-N2011R
    Octyl gallate (Standard)

    没食子酸辛酯 (Standard)

    Inhibitor
    Octyl gallate (Standard) 是 Octyl gallate 的分析标准品。本产品用于研究及分析应用。Octyl gallate (Progallin O) 广泛用作食品添加剂,具有抗菌、抗氧化作用。具有选择性、敏感性的荧光特性。Octyl gallate 对 HSV-1,水泡性口炎病毒 (VSV) 和脊髓灰质炎病毒显具有显着的抗病毒作用。
    Octyl gallate (Standard)
  • HY-W073074
    Mesoporphyrin IX dihydrochloride

    中卟啉IX二盐酸盐

    Inhibitor
    Mesoporphyrin IX (dihydrochloride) 是一种光敏剂,可用于修饰脂质体。Mesoporphyrin IX (dihydrochloride) 在水泡性口炎病毒 (VSV) 中可以插入脂质囊泡并扰乱病毒膜组织,诱导 VSV 糖蛋白交联,从而抑制病毒活性。
    Mesoporphyrin IX dihydrochloride
  • HY-P0328
    VSV-G tag Peptide 99.03%
    VSV-G Peptide 是一种源于水泡性口炎病毒糖蛋白的由 11 个氨基酸残基组成的多肽。
    VSV-G tag Peptide
  • HY-N11056
    Justicidin C Inhibitor
    Justicidin C 是一种抗病毒木脂素。Justicidin C 对水泡性口炎病毒表现出较强的抗病毒活性,对兔肺细胞 (RL-33) 表现出较低的细胞毒性。
    Justicidin C
  • HY-N2812
    Epipodophyllotoxin acetate Inhibitor
    Epipodophyllotoxin acetate (4-O-Epipodophyllotoxinyl acetate; compound 4) 是一种环木脂素,具有抗肿瘤和抗病毒活性。Epipodophyllotoxin acetate 抑制 HSVVSVIC50 值分别为 0.2 和 0.1 μg/mL。
    Epipodophyllotoxin acetate