2. Anti-infection
  3. VSV
  4. SMU-V18

SMU-V18 是一种水疱性口炎病毒 (VSV) 抑制剂，EC50 为 6.2 μM。SMU-V18 可抑制 VSV-GFP 荧光强度、病毒 mRNA/蛋白表达及子代病毒复制。SMU-V18 干扰病毒感染早期阶段，对野生型 VSV (VSV-WT) 也有效。SMU-V18 可抑制小鼠组织中的 VSV-GFP 并延长小鼠生存期。SMU-V18 可用于水疱性口炎病毒 (VSV) 感染的研究。

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SMU-V18

SMU-V18 Chemical Structure

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SMU-V18 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SMU-V18 is a vesicular stomatitis virus (VSV) inhibitor, with an EC50 of 6.2 μM. SMU-V18 inhibits VSV-GFP fluorescence intensity, viral mRNA/protein expression, and progeny virus replication. SMU-V18 interferes with early viral infection stages, also effective against wild-type VSV (VSV-WT). SMU-V18 inhibits VSV-GFP in mouse tissues and prolongs survival. SMU-V18 can be used for the study of vesicular stomatitis virus (VSV) infection[1].

体外研究
(In Vitro)

SMU-V18 (1.2-40 μM, 24 h) 在 HeLa 细胞中显著抑制 VSV-GFP 复制 (EC50 = 6.2 μM)，降低 GFP 荧光强度、VSV-P mRNA 和 GFP 表达[1]。
SMU-V18 (5-20 μM, 24 h) 有效抑制子代 VSV-GFP 的释放[1]。
SMU-V18 (5-20 μM, 6-24 h) 在 Vero 细胞中显著抑制 VSV-WT 复制，减少 VSV-WT 斑块形成，并在不同 MOI 和孵育时间下降低病毒 mRNA 水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SMU-V18 相关抗体:

Real Time qPCR[1]

Cell Line: HeLa cells
Concentration: 5, 10, 20, 40 μM
Incubation Time: 6, 12, 24 h
Result: Reduced the VSV-P mRNA levels.
体内研究
(In Vivo)

SMU-V18 (25-50 mg/kg, 腹腔注射, 每日一次, 5 天) 在小鼠组织中显著降低 VSV-GFP 的复制[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: VSV-GFP (5×107 PFU) was intraperitoneally injected into 6-week-old male BALB/c mice to establish a VSV infection animal model[1]
Dosage: 25 mg/kg, 50 mg/kg
Administration: i.p., once daily, 5 days
Result: Achieved significant inhibition of VSV-GFP replication in multiple tissues (intestine, liver, kidney, brain) of infected mice.
Showed no severe weight loss (body weight decreased initially then gradually recovered) and significantly improved survival rate.
Reduced VSV-induced splenomegaly, with a significant decrease in the spleen index.
Appeared reduced progeny VSV replication in mouse serum.
Showed alleviation of VSV-GFP-induced pathological damage in multiple organs (heart, lung, intestine), restoring myocardial fiber order, improving alveolar structure, and maintaining intestinal villus integrity .
分子量

387.31

Formula

C19H12F3N3O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SMU-V18 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SMU-V18VSVVesicular Stomatitis VirusInhibitorinhibitorinhibit

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产品名称：
SMU-V18
目录号：
HY-175769
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