2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. AA29504

A29504 是一种具有γ -氨基丁酸 (GABAA(HY-L120) 受体活性的氨基甲酸乙酯。 AA29504 抑制中枢神经系统中神经递质γ -氨基丁酸传递。AA29504 能够用于治疗焦虑、失眠等神经精神疾病的研究。

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AA29504 Chemical Structure

AA29504 Chemical Structure

CAS No. : 945828-50-2

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规格 价格 是否有货 数量
5 mg ￥2953
3 - 4 周
10 mg ￥4717
3 - 4 周
25 mg ￥8489
3 - 4 周
50 mg   询价  
100 mg   询价  

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Customer Review

AA29504 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AA29504 is a ethyl carbamate with γ-aminobutyric acid (GABAA(HY-L120) receptor activity. AA29504 inhibits the delivery of the neurotransmitter gamma-aminobutyric acid in the central nervous system. AA29504 can be used to research anxiety, insomnia and other neuropsychiatric diseases [1].

体外研究
(In Vitro)

AA29504 (0.1, 1, 10, 100 μM, 72 h) 在非洲爪蟾卵母细胞中可开启 Kv7 电压门控钾离子 (KCNQ) 通道[1]。
AA29504 (1 μM) 对在非洲爪蟾卵母细胞中表达的GABAA受体有正向调节作用, EC501.4 μM[1]。
AA29504 (1 μM, 10 s) 在前额叶皮层锥体神经元中对加波沙朵 (gaboxadol) 诱导的电流有显著增强作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AA29504 相关抗体:
体内研究
(In Vivo)

AA29504 (0.5, 2 或 4 mg/kg, 皮下注射) 在雄性 SD (Spraguee Dawley) 大鼠中有抗焦虑作用[1]。
AA29504 (4 mg/kg, 皮下注射)在乙醇的协同作用下显著减弱了雄性 SD 大鼠的运动协调性[1]。
AA29504 (10 mg/kg, 皮下注射)在雄性维斯塔大鼠中对杏仁核点燃的癫痫发作有治疗作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Spraguee Dawley rats [1]
Dosage: 0.5, 2 or 4 mg/kg
Administration: Subcutaneous injections
Result: Reduced the number of vocalizations at 4 mg/kg and reversed partially the freezing behavior at 2 mg/kg.
Animal Model: Male Spraguee Dawley rats [1]
Dosage: 4 mg/kg
Administration: Subcutaneous injections
Result: Reduced the time the rats stayed on the rotarod at 4 mg/kg.
Animal Model: Male Wistar rats [1]
Dosage: 10 mg/kg
Administration: Subcutaneous injections
Result: Reduced from 4.9 to 2.0 in amygdala kindled seizures response.
分子量

327.42

Formula

C19H25N3O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AA29504 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AA29504945828-50-2AA 29504AA-29504GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorXenopus oocytespyramidal cells ofprefrontal cortexGABAA receptorInhibitorinhibitorinhibit

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目录号：
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