2. Apoptosis
  3. TNF Receptor
  4. ABI793

ABI793 是一种人 IgG1 抗人CD154 (CD40 配体) 单克隆抗体。ABI793 通过阻断 CD154-CD40 (IC50 = 75 nM) 信号通路抑制免疫反应。ABI793 能有效预防肾移植排斥反应。ABI793 可用于免疫排斥反应的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

ABI793 Chemical Structure

ABI793 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
1 mg   询价  
5 mg   询价  
10 mg   询价  

* Please select Quantity before adding items.

Customer Review

ABI793 相关抗体

Top Publications Citing Use of Products

查看 TNF Receptor 亚型特异性产品:

查看所有亚型
TNFRSF1A/CD120a TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ABI793 is a human IgG1 antihuman CD154 (CD40 ligand) monoclonal antibody. ABI793 inhibits immune response by blocking the CD154-CD40 (IC50 = 75 nM) signaling pathway. ABI793 effectively prevents kidney transplant rejection. ABI793 can be used for research on immunological rejection[1][2].

IC50 & Target

TNFSF5/CD40L/CD154
体外研究
(In Vitro)

ABI793 以浓度依赖的方式抑制 CD154 和 CD40 结合 (IC50 = 75nM)[1]。
ABI793 (4 天) 抑制 IL-4 刺激的 B 细胞增殖 (IC50 = 73 nM)[1]。
ABI793 (5 天) 抑制人混合淋巴细胞反应 (MLR) (IC50 = 320 ng/mL)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ABI793 相关抗体:
体内研究
(In Vivo)

ABI793 (20 mg/kg, 静脉注射, 术后第 0, 1, 4, 11, 18, 28, 56 和 84 天) 显著延长了移植肾脏的食蟹猴的存活时间，并有效预防了移植排斥反应[1]。
ABI793 (20 mg/kg, 静脉注射, 术后第 0, 1, 4, 11, 18, 28, 56 和 84 天) 显著延长了恒河猴肾移植的存活时间[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Renal allograft or autograft transplantation in Cynomolgus monkeys (3-8 kg)[1]
Dosage: 20 mg/kg
Administration: Intravenous injection (i.v.) on postoperative days 0, 1, 4, 11, 18, 28, 56, and 84
Result: Significantly prolonged the survival time of transplanted kidneys (median survival of 108 days). Did not cause acute tubular necro-sis (ATN) or thrombocytopenia in autograft transplantation.
Animal Model: Renal allograft transplantation in rhesus monkeys (4-6 years, 4-7 kg)[2]
Dosage: 20 mg/kg
Administration: Intravenous injection (i.v.) on postoperative days 0, 1, 4, 11, 18, 28, 56, and 84
Result: Significantly prolonged kidney transplant survival time (median survival of 149 days). Did not cause abnormal liver and kidney function or hematological toxicity.
基因 ID

959  [NCBI]

Accession
靶点

TNFSF5/CD40L/CD154
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ABI793 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ABI793ABI 793ABI-793TNF ReceptorTumor Necrosis Factor ReceptorTNFRCD154immunological rejectionrenal transplantInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
ABI793
目录号：
HY-P991557
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z