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  4. ACHM-025

ACHM-025 是一种前药，它会被 AKR1C3 选择性激活为一种氮芥类 DNA 烷化剂。ACHM-025 可用于癌症研究，如白血病。

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ACHM-025

ACHM-025 Chemical Structure

CAS No. : 2377718-85-7

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ACHM-025 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ACHM-025 is a prodrug, which is selectively activated by AKR1C3 to a nitrogen mustard DNA alkylating agent. ACHM-025 can be used for the research of cancer, such as leukemia[1].

体外研究
(In Vitro)

ACHM-025 仅对过表达 AKR1C3 的 HCT116 细胞表现出强效的细胞毒性，其 IC50 值为 0.03μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ACHM-025 相关抗体:
体内研究
(In Vivo)

ACHM-025 (25 mg/kg，腹腔注射，在第 0、7、14 天给药) 在接种化疗耐药 T-ALL PDX (ALL-31) 的雌性 NOD/SCID 或 NSG 小鼠中，显著降低外周血人白血病细胞比例并延长生存期[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female NOD/SCID or NSG mice inoculated with chemoresistant T-ALL PDX (ALL-31)[1]
Dosage: 25 mg/kg
Administration: Intraperitoneally injection, at days 0, 7, 14
Result: Reduced the proportion of human leukemia cells in peripheral blood to <1% and maintained it for more than 10 weeks.
Extended the median event-free survival (EFS) from 16.7 days to >332 days.
Showed no relapse within the >300-day observation period, and no leukemia cells are detected in organs such as bone marrow and spleen after dissection, achieving functional cure in 5 mice.
分子量

544.62

Formula

C17H28N4O10S3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ACHM-025 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ACHM-0252377718-85-7ACHM025ACHM 025OthersProdrugAKR1C3nitrogen mustard DNA alkylating agentleukemiaInhibitorinhibitorinhibit

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目录号：
HY-172314
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