1. Immunology/Inflammation Vitamin D Related/Nuclear Receptor
  2. Glucocorticoid Receptor
  3. AL-438

AL-438 是一种有效的,选择性和具有口服活性的糖皮质激素受体 (glucocorticoid receptor) 调节剂,对糖皮质激素受体、孕激素受体、盐皮质激素受体、雄激素受体、雌激素受体的 Ki 分别为 2.5、1786、53、1440、>1000 nM。AL-438 具有抗炎活性。

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AL-438 Chemical Structure

AL-438 Chemical Structure

CAS No. : 239066-73-0

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AL-438 is a potent, selective and orally active glucocorticoid receptor modulator with Kis of 2.5, 1786, 53, 1440, >1000 nM for glucocorticoid receptor, progesterone receptor, mineralocorticoid receptor, androgen receptor, estrogen receptor, respectively. AL-438 shows antiinflammatory activity[1][2].

IC50 & Target

Ki: 2.5 nM (glucocorticoid receptor)[1]

体外研究
(In Vitro)

AL-438 (1 µM) 降低 ATDC5 细胞中 LPS 诱导的 IL-6 的生成[1]
AL-438 (0-1 µM; 1 h+24 h) 抑制 HSKF1501 细胞中 IL-1β (2 ng/ml) 诱导的 IL-6 表达[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

AL-438 (1, 10, 100 mg/kg; p.o.) 在大鼠体内显示出抗炎活性[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague Dawley rats (carrageenan paw edema model)[2]
Dosage: 1, 10, 100 mg/kg
Administration: P.o.
Result: Showed antiinflammatory activity with ED50 value of 11 mg/kg in acute inflammation assay.
分子量

347.45

Formula

C23H25NO2

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
AL-438
目录号:
HY-114154
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