2. Apoptosis
  3. Apoptosis
  4. Amyloid 17-42

Amyloid 17-42  (Synonyms: Aβ(17-42))

目录号: HY-P3779
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摩尔计算器

Amyloid 17-42 (Aβ(17-42)) 是阿尔茨海默病弥漫性斑块和唐氏综合症小脑前淀粉样蛋白的主要成分，由淀粉样蛋白前体蛋白 (APP) 的 α 和 γ 分泌酶裂解衍生而来。Amyloid 17-42 可通过 Fas 样/caspase-8 激活途径诱导神经细胞凋亡。

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Custom Peptide Synthesis

Amyloid 17-42 Chemical Structure

Amyloid 17-42 Chemical Structure

CAS No. : 155178-13-5

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Amyloid 17-42 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Amyloid 17-42 (Aβ(17-42)) is a major constituent of diffuse plaques in Alzheimer's disease and cerebellar pre-amyloid in Down's syndrome, derived by alpha- and gamma-secretase cleavage of the amyloid precursor protein (APP). Amyloid 17-42 can induce neuronal apoptosis via a Fas-like/caspase-8 activation pathway[1].

体外研究
(In Vitro)

Amyloid 17-42 (20 μM; 48 h) leads to apoptosis in SH-SY5Y and IMR-32 cells[1].
Amyloid 17-42 (20 μM; 48 h, 72 h) activates caspase-8 and caspase-3, induced poly(ADP-ribose) polymerase cleavage[1].
Amyloid 17-42 (20 μM) moderately activates c-Jun N-terminal kinase (JNK)[1].
Amyloid 17-42 induces neuronal apoptosis via a Fas-like/caspase-8 activation pathway[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Amyloid 17-42 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: SH-SY5Y and IMR-32 cells
Concentration: 0-30 μM
Incubation Time: 48 h
Result: Caused the death of SH-SY5Y and IMR-32 human neuroblastoma cells.

Apoptosis Analysis[1]

Cell Line: SH-SY5Y cells
Concentration: 20 μM
Incubation Time: 48 h
Result: Showed shrunken cell bodies, condensed and fragmented chromatin, and increased amounts of cytoplasmic oligonucleosomes.

Western Blot Analysis[1]

Cell Line: SH-SY5Y cells
Concentration: 20 μM
Incubation Time: 48, 72 h; 18 h, 24 h
Result: Reduced procaspase-3 and increased cleaved caspase-3 in cells.
Reduced procaspase-8 in cells.
Lead to early activation of JNK.
分子量

2577.05

Formula

C119H194N28O33S
CAS 号
Sequence Shortening

LVFFAEDVGSNKGAIIGLMVGGVVIA
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Amyloid 17-42 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

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Keywords:

Amyloid 17-42155178-13-5Aβ(17-42)ApoptosisAlzheimer's diseaseDown's syndromethe amyloid precursor protein (APP)neuronalapoptosisInhibitorinhibitorinhibit

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