2. GPCR/G Protein
  3. GCGR
  4. ANT308

ANT308 是一种血管活性肠肽 (VIP receptor) 拮抗剂。ANT308 显著增强 T 细胞的活化和增殖。ANT308 通过抑制 VIP-VPAC2 信号传导并降低 MCAM 和 N-cadherin 的表达，抑制黑色素瘤细胞的迁移和转移，并诱导细胞凋亡 (apoptosis)。ANT308 可用于急性髓系白血病 (AML) 和葡萄膜黑色素瘤 (UVM) 的研究。

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ANT308

ANT308 Chemical Structure

CAS No. : 2871680-36-1

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ANT308 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ANT308 is a vasoactive intestinal polypeptide (VIP receptor) antagonist. ANT308 significantly enhances the activation and proliferation of T cells. ANT308 inhibits the migration and metastasis, induces apoptosis of melanoma tumor cells by inhibiting VIP-VPAC2 signaling and reducing the expression of MCAM and N-cadherin. ANT308 can be used for the study of acute myeloid leukemia (AML) and uveal melanoma (UVM)[1][2].

体外研究
(In Vitro)

ANT308 (1-10 μM, 48 h) 显著增强 CD4+ 和 CD8+ T 细胞中 CD69 和 Ki67 的表达[1]。
ANT308 (0.1-10 μM, 72 h) 剂量依赖性地降低 B16F10 和 HT-144 细胞的活力[2]。
ANT308 (0 μM, 72 h) 降低 S 期细胞比例，并诱导 B16LS9 和 Mel 290 细胞凋亡[2]。
ANT308 (10 μM, 72 h) 显著抑制 B16LS9、Mel290 和 HT-144 细胞系中的细胞迁移[2]。
ANT308 (72 h)通过抑制 VIP-VPAC2 信号传导来降低 MCAM 和 N-钙粘蛋白的表达[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ANT308 相关抗体:

Cell Viability Assay[2]

Cell Line: B16F10 and HT-144 cells
Concentration: 0.1, 1, 5 and 10 μM
Incubation Time: 72 h
Result: Decreased the numbers of viable B16F10 and HT-144 cells by around 46 % and 27 %, respectively, compared to control cultures with 5 μM twice daily.

Apoptosis Analysis[2]

Cell Line: B16LS9 and Mel 290 cells
Concentration: 10 μM
Incubation Time: 72 h
Result: Increased percentages of apoptotic cells.

Cell Cycle Analysis[2]

Cell Line: B16LS9 and Mel 290 cells
Concentration: 10 μM
Incubation Time: 72 h
Result: Decreased cells in the S phase.

Cell Migration Assay [2]

Cell Line: B16LS9, B16F10, Mel 290 cells, HT-144 cells
Concentration: 10 μM
Incubation Time: 8 h
Result: Significantly inhibited cell migration in the B16LS9, Mel290, and HT-144 cell lines
体内研究
(In Vivo)

ANT308 (6 nmol，皮下注射，每日一次，持续 10-14 天) 显著延长小鼠生存期，并降低 AML 模型中的肿瘤负荷[1]。
ANT308 (100 μg/100 μL PBS，皮下注射，每天两次，持续 10 天) 可减少小鼠眼内或皮下黑色素瘤注射后肝转移瘤的数量和大小，并显示出减少原发性肿瘤部位肿瘤体积的趋势[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: P815 cells induced AML model established in DBA/2j (H2Kd) mice[1]
Dosage: 6 nmol
Administration: Subcutaneous injection (s.c.), once daily for 10-14 weeks
Result: Significantly prolonged the survival period of mice and reduced the tumor burden.
Animal Model: B16LS9 induced UVM model and B16LS9 or B16LS9 induced subcutaneous melanoma model established in female C57BL6/J mice (8-10 weeks) and NRG (NOD Rag gamma) mice (10-11 months old)[2]
Dosage: 100 μg/100 μL PBS
Administration: Subcutaneous injection (s.c.), twice a day for 10 days
Result: Significantly reduced the number of liver metastases.
Reduced MCAM, but had no significant effect on N-cadherin expression.
had no significant effect on subcutaneous tumor volume.
分子量

3467.10

Formula

C156H261N47O40S
CAS 号
Sequence

Lys-Pro-Arg-Arg-Pro-Tyr-Thr-Ser-Asp-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Leu-Ile-Leu-Asn
Sequence Shortening

KPRRPYTSDYTRLRKQMAVKKYLNLILN
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ANT308 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ANT3082871680-36-1ANT 308ANT-308GCGRGlucagon ReceptorVIPPEGylationpeptide stapleacute myeloid leukemiaInhibitorinhibitorinhibit

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