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  4. Anti-inflammatory agent 89

Anti-inflammatory agent 89 (5c) 抑制所有哮喘特征。Anti-inflammatory agent 89 通过其皮质类固醇和 H2S 释放成分对肺部结构的恢复和肺部炎症的减轻均有显著作用，有望用于哮喘的研究。

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Anti-inflammatory agent 89 Chemical Structure

Anti-inflammatory agent 89 Chemical Structure

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Anti-inflammatory agent 89 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-inflammatory agent 89 (5c) inhibits all asthma features. Anti-inflammatory agent 89 exhibits a significative effect on the restoration of pulmonary structure and reduction of lung inflammation through both its corticosteroid and H2S releasing component, which is proming for research of Asthma[1].

体外研究
(In Vitro)

Anti-inflammatory agent 89 (100 μM, 24 h) 没有降低 RBL-2H3 细胞活力[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-inflammatory agent 89 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: RBL-2H3 cells
Concentration: 100 μM
Incubation Time: 24 h
Result: Did not show any reduction in cell viability compared to the vehicle in RBL-2H3 cells.
体内研究
(In Vivo)

Anti-inflammatory agent 89 (1-2 mg/kg, 腹膜注射, 在第 0 天和第 7 天致敏前 30 分钟给药，持续 21 天) 通过作用于 Ovalbumin (OVA) (HY-W250978) 致敏小鼠的肺部炎症抑制哮喘样特征[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c mice (20 g, 8 weeks) of OVA sensitization[2]
Dosage: 1-2 mg/kg
Administration: i.p., administrated 30 min before ovalbumin sensitization on days 0 and 7 for 21 days
Result: Inhibited bronchial hyperreactivity in a dose-dependent manner and reduced pulmonary IL-13 levels that well correlate with bronchial reactivity in OVA (HY-W250978) sensitized mice. Reduced OVA-induced α-SMA over-expression and restored the structure of the alveolar septa, bronchial epithelium and airway smooth muscle in OVA (HY-W250978) sensitized mice.
分子量

569.71

Formula

C31H39NO7S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anti-inflammatory agent 89 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-inflammatory agent 89Othersasthmapulmonary structurelung inflammationcorticosteroidH2S releasing componentInhibitorinhibitorinhibit

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Anti-inflammatory agent 89
目录号：
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