2. Anti-infection
  3. Bacterial
  4. Antibacterial agent 122

Antibacterial agent 122 (compound 15) 是一种硫脲衍生物，具有抗分枝杆菌活性，低细胞毒性，可用于肺结核相关研究。

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Antibacterial agent 122 Chemical Structure

Antibacterial agent 122 Chemical Structure

CAS No. : 109310-99-8

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Antibacterial agent 122 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antibacterial agent 122 (compound 15) is a thiourea derivative with anti-mycobacterial activity and low cytotoxicity. Antibacterial agent 122 can be used for tuberculosis-related studies[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
RAW264.7 CC50
196.7 μM
Compound: 15
Cytotoxicity against LPS-stimulated mouse RAW264.7 cells after 24 hrs by MTT assay
Cytotoxicity against LPS-stimulated mouse RAW264.7 cells after 24 hrs by MTT assay
[PMID: 34890996]
RAW264.7 IC50
28.4 μM
Compound: 15
Anti-inflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as reduction in TNFalpha protein expression level after 24 hrs by ELISA
Anti-inflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as reduction in TNFalpha protein expression level after 24 hrs by ELISA
[PMID: 34890996]
RAW264.7 IC50
47.9 μM
Compound: 15
Anti-inflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as reduction in IL1beta protein expression level after 24 hrs by ELISA
Anti-inflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as reduction in IL1beta protein expression level after 24 hrs by ELISA
[PMID: 34890996]
RAW264.7 IC50
8.1 μM
Compound: 15
Inhibition of NO production in mouse RAW264.7 cells incubated for 24 hrs by Griess reagent based analysis
Inhibition of NO production in mouse RAW264.7 cells incubated for 24 hrs by Griess reagent based analysis
[PMID: 34890996]
体外研究
(In Vitro)

Antibacterial agent 122 (compound 15) (25-200 µM, 24 h) inhibits M. tuberculosis H37Rv with the MIC50 value of 5.9 µM and inhibits NO production in LPS-stimulated RAW 264.7 cell cultures with an IC50 value of 8.1µM[1].
Antibacterial agent 122 (compound 15) (25-200 µM) acts on NO scavenging with an IC50 value of 184.2 µM, and almost completely inhibits iNOS expression in LPS-stimulated RAW264.7 macrophages at a concentration of 100 µM[1].
Antibacterial agent 122 (compound 15) (0-200 µM, 24 h) inhibits TNF-α and IL-1β production in LPS-stimulated macrophages with the IC50 values of 28.4 µM and 47.9 µM, respectively[1].
Antibacterial agent 122 (compound 15) (25-100 µM, 4 days) inhibits M. tuberculosis M299 with an MIC50 value of 24.7 µM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antibacterial agent 122 相关抗体:
分子量

302.35

Formula

C15H14N2O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antibacterial agent 122 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antibacterial agent 122109310-99-8Antibacterial agent122Antibacterial agent-122BacterialTuberculosisMycobacteriumThioureaAntibacterialInhibitorinhibitorinhibit

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产品名称：
Antibacterial agent 122
目录号：
HY-151356
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