2. Anti-infection
  3. Bacterial
  4. Antibacterial agent 123

Antibacterial agent 123 (compound 111) 是一种有效的膜破坏剂，可以对抗耐药的革兰氏阳性菌。

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Antibacterial agent 123 Chemical Structure

Antibacterial agent 123 Chemical Structure

CAS No. : 2615254-55-0

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Antibacterial agent 123 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antibacterial agent 123 (compound 111) is a potent membrane-disrupting agent to combat antibiotic-resistant Gram-positive bacteria[1].

体外研究
(In Vitro)

Antibacterial agent 123 (compound 111) shows excellent activity (MIC<0.0625 μg/mL) toward S. aureus strains[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antibacterial agent 123 相关抗体:
体内研究
(In Vivo)

Antibacterial agent 123 (compound 111) (p.o. (10 mg/kg) and i.v. (0.5 mg/kg); once) exhibits favorable pharmacokinetics profiles[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female CD-1 mice[1]
Dosage: 0.5 mg/kg, 10 mg/kg
Administration: p.o. (10 mg/kg) and i.v. (0.5 mg/kg); once (Pharmacokinetic Analysis)
Result: Pharmacokinetic Parameters of Antibacterial agent 123 in Female CD-1 Mice[1].
pharmacokinetic indices dose i.v., p.o. (mg/kg) AUC0-24 (i.v., h·ng/mL) Vd (i.v., mL/kg) CL (i.v., mL/(kg·h)) t1/2 (i.v., h) AUC0-24 (p.o., h·ng/mL) Cmax (p.o., ng/mL) F (%)
compound 111 0.5, 10 (4.20 × 103) ± 308 322 ± 24 119 ± 9.2 1.88 ± 0.08 (4.33 × 104) ± 543 (3.10 × 103) ± 780 51.6 ± 5.2
分子量

441.25

Formula

C17H8F9N3O
CAS 号
Unlabeled CAS

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antibacterial agent 123 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antibacterial agent 1232615254-55-0Antibacterial agent123Antibacterial agent-123Bacterial5-aminoquinolin-4-onesAntibacterialbacteriaS. aureusmembrane-disruptingInhibitorinhibitorinhibit

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