1. Anti-infection
  2. Bacterial
  3. Antibacterial agent 130

Antibacterial agent 130 是一种 1,1-二酰硫半乳糖苷,用于靶向铜绿假单胞菌 (Pseudomonas aeruginosa) LecAAntibacterial agent 130 对 LecA 具有较高的亲和力 (Kd=1 μM)。Antibacterial agent 130 具有抗菌膜活性,但缺乏杀菌活性。LecA,一种来自铜绿假单胞菌的凝集素和毒力因子,参与细菌粘附和生物膜的形成。

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Antibacterial agent 130 Chemical Structure

Antibacterial agent 130 Chemical Structure

CAS No. : 1502721-60-9

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antibacterial agent 130 is a 1,1-diarylthiogalactoside, used for targeting the Pseudomonas aeruginosa LecA. Antibacterial agent 130 shows high affinity toward LecA (Kd=1 μM). Antibacterial agent 130 has antibiofilm activity, but lacks bactericidal activity. LecA, a lectin and virulence factor from Pseudomonas aeruginosa involved in bacterial adhesion and biofilm formation[1].

体外研究
(In Vitro)

Antibacterial agent 130 (化合物 8a) (0.08-5 mM; 2-24 h) 剂量依赖性抑制细菌生物膜的形成,在 5 mM 剂量下的抑制率是 100%[1]
Antibacterial agent 130 (0.01-5 mM; 24 h) 浓度高于1.25 mM 时对 MRC-5 细胞系 (人胎儿肺成纤维细胞) 有细胞毒性[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

496.53

Formula

C23H28O10S

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

Antibacterial agent 130 相关分类

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产品名称:
Antibacterial agent 130
目录号:
HY-152175
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