DRP1 抗体 (YA6305)

DRP1 Antibody (YA6305) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to DRP1.

DNM1L 是一种参与线粒体 (mitochondrial) 和过氧化物酶体 (peroxisomal) 分裂的关键蛋白。它通过寡聚化形成膜相关管状结构，包裹在分裂位点周围，依赖 GTP 水解机制收缩并切断线粒体膜 (PubMed:23530241，PubMed:23584531，PubMed:33850055)。其特异性募集由膜受体 (如 MFF、MIEF1 和 MIEF2) 介导 (PubMed:23283981，PubMed:23921378，PubMed:29899447)。GTP 水解后，DNM1L 从受体解离并卷曲成闭合环状结构，可能足以切断双层膜 (PubMed:29899447)。在 PINK1-PRKN 通路下游促进线粒体分裂 (PubMed:32484300)，并在有丝分裂期间调控线粒体分裂 (PubMed:19411255，PubMed:26992161，PubMed:27301544，PubMed:27328748)。通过抑制氧化损伤，确保部分有丝分裂后神经元 (如浦肯野细胞，Purkinje cells) 的存活 (By similarity)。对正常脑发育 (包括小脑) 至关重要 (PubMed:17460227，PubMed:26992161，PubMed:27145208，PubMed:27301544，PubMed:27328748)，并在神经管形成期间参与发育调控的凋亡 (By similarity)。其 Ser-637 磷酸化的节律性调控对线粒体 ATP 生成的昼夜节律控制必不可少 (PubMed:29478834)。过表达时会抑制过氧化物酶体分裂。

O00429

Predicted band size: 83 kDa; Observed band size: 83 kDa

Protein A

Non-conjugated

Unmodified

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Monoclonal

Rabbit

Human, Mouse, Rat

IHC: 1:200-1000; WB: 1:1000-5000; ICC/IF: 1:200-1000; ELISA: 1:5000-20000; IP: 1:50-200

WB, IHC-P, ICC/IF, IP, ELISA

液体

Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG