2. 抗体
  3. 一抗
  4. 单克隆抗体 重组抗体
  5. Lrp2/Megalin 抗体 (YA3473)

Lrp2/Megalin 抗体 (YA3473)

目录号: HY-P83746
抗体使用指南 技术支持

Lrp2/Megalin Antibody (YA3473) 是一个兔来源、无偶联标记、抗 Lrp2/Megalin 的 IgG 单克隆抗体。

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规格 是否有货
50 μL   询价  
100 μL   询价  

* Please select Quantity before adding items.

Top Publications Citing Use of Products

【WB: 蛋白质免疫印迹; IHC-P: 石蜡切片样本的免疫组织化学; IHC-F: 冰冻切片样本的免疫组织化学; ICC/IF: 细胞免疫荧光; IF-Tissue: 组织免疫荧光; mIHC: 多重荧光免疫组化; IP: 免疫沉淀; ChIP: 染色质免疫沉淀; FC: 流式细胞术; ELISA: 酶联免疫吸附试验】

  • 生物活性

  • 技术参数

  • 产品性质

  • 产品资料

描述

Lrp2/Megalin Antibody (YA3473) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Lrp2/Megalin.
研究背景

The protein encoded by The related gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. The glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. The protein also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of The membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in The related gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).
基因 ID
蛋白数据库
中文名
Lrp2/Megalin 抗体 (YA3473)
同用名
Low-density lipoprotein receptor-related protein 2; LRP-2; Glycoprotein 330; gp330; Megalin; LRP2; DBS
分子量

Predicted band size: 522 kDa; Observed band size: 600 kDa
纯度

affinity purified.
亚细胞定位

Apical cell membrane, Endosome lumen, Membrane, coated pit, Cell projection, dendrite, axon.
偶联

Non-conjugated
修饰

Unmodified
研究领域

Cardiovascular
产品类别

Primary Antibody; Recombinant Rabbit Monoclonal Antibody
克隆性

Monoclonal, Recombinant
宿主

Rabbit
反应物种

Human, Mouse, Rat
推荐稀释比例

WB: 1:2000; IHC-P: 1:1000; IF-Tissue: 1:200
应用

WB, IHC-P, ICC/IF
阳性对照

Human kidney tissue lysate, mouse kidney tissue lysate, rat kidney tissue lysate, human kidney tissue, mouse kidney tissue, rat kidney tissue.
性状

液体
组分

Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
保存条件 & 期限

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
运输条件

Shipping with blue ice.
同型

IgG
免疫原

Synthetic peptide within human Lrp2 aa 2,500-3,200 / 4,655.
数据库

Entrez Gene: 4036 Human ; 14725 Mouse ; 29216 Rat

SwissProt: P98164 Human ; A2ARV4 Mouse ; P98158 Rat

OMIM: 222448 Human

文件资料
抗体使用指南 (1083 KB)

Lrp2/Megalin Antibody (YA3473) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Lrp2/Megalin Antibody (YA3473)
目录号：
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