2. 抗体
  3. Primary Antibodies
  4. phospho-ERK1 + 2 (Thr183/Tyr185) 抗体

phospho-ERK1 + 2 (Thr183/Tyr185) 抗体

目录号: HY-P81156
抗体使用指南

phospho-ERK1 + 2 (Thr183/Tyr185) Antibody 是一个非偶联、分子量约 42/44 kDa、兔来源、抗 phospho-ERK1 + 2 (Thr183/Tyr185) 多克隆抗体。phospho-ERK1 + 2 (Thr183/Tyr185) Antibody 可用于：人、小鼠背景下 WB, ELISA, IHC-P, IHC-F, ICC, IF 实验，且不带标记。

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50 μL   询价  
100 μL   询价  

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描述

phospho-ERK1 + 2 (Thr183/Tyr185) Antibody is an unconjugated, approximately 42/44 kDa, rabbit-derived, anti-phospho-ERK1 + 2 (Thr183/Tyr185) polyclonal antibody. phospho-ERK1 + 2 (Thr183/Tyr185) Antibody can be used for: WB, ELISA, IHC-P, IHC-F, ICC, IF expriments in human, mouse, and predicted: rat, chicken, dog, cow, horse, rabbit, guinea pig background without labeling.
研究背景

激酶和磷酸酶（Kinases and Phosphatases） 丝裂原活化蛋白激酶-ERK（Mitogen-activated protein kinase 1, MAPK-1； P42-MAPK；Extracellular signal-regulated kinase 2, ERK-2;MAPK-2曾用名还有：, ERK2，MAPK-α，MAPK1，MAPK2, p42MAPK）是一组可以被多种细胞外信号即获得蛋白丝/苏氨酸激酶，处于胞浆信号传导通路的终末位置，活化后转位到核内，作用于核内转录因子，调节基因表达。它主要参与生长因子、激素、细胞因子、应激等各种刺激下细胞的反应、细胞的生长、分化过程。 经研究证实，MAPK信号转导通路存在于大多数细胞内，在将细胞外刺激信号转导至细胞及其核内，并引起细胞生物学反应（如细胞增殖、分化、转化及凋亡等）的过程中具有至关重要的作用。研究表明，MAPK信号转导通路在细胞内具有生物进化的高度保守性，在低等原核细胞和高等哺乳类细胞内，目前均已发现存在着多条并行的MAPK信号通路，不同的细胞外刺激可使用不同的MAPK信号通路，通过其相互调控而介导不同的细胞生物学反应。
基因 ID

5595
中文名
磷酸化丝裂原活化蛋白激酶1/2抗体
同用名
ERK1 + ERK2 (phospho Thr183/Tyr185); phospho-ERK1/MAPK-1/2(Thr183/Tyr185); ERK 1; ERK 2; ERK-2; ERK1; ERK2; ERT1; ERT2; Extracellular signal regulated kinase 1; Extracellular signal regulated kinase 1; Extracellular signal regulated kinase 2; Extracellular signal regulated kinase 2; Extracellular signal-regulated kinase 2; HS44KDAP; HUMKER1A; Insulin stimulated MAP2 kinase; MAP kinase 1; MAP kinase 2; MAP kinase isoform p42; MAP kinase isoform p44; MAPK 1; MAPK 2; MAPK1; MAPK2; MGC20180; Microtubule associated protein 2 kinase; Mitogen activated protein kinase 1; Mitogen activated protein kinase 1; Mitogen activated protein kinase 2; Mitogen-activated protein kinase 1; Mitogen-activated protein kinase 2; MK01_MOUSE; p38; p40; p41; p41mapk; p42 MAPK; p42-MAPK; p42MAPK; p42MAPK; p44 ERK1; p44 MAPK; p44ERK1; p44ERK1; p44MAPK; p44MAPK; PRKM 1; PRKM 1; PRKM 2; PRKM 2; PRKM1; PRKM2; Protein kinase mitogen activated 1; Protein kinase mitogen activated 1; Protein kinase mitogen activated 2; Protein kinase mitogen activated 2; Protein tyrosine kinas.
分子量

Predicted band size: 42/44kDa
纯度

affinity purified
亚细胞定位

Cytoplasm, cytoskeleton, spindle. Nucleus. Cytoplasm, cytoskeleton, centrosome. Cytoplasm. Note=Associated with the spindle duringprometaphase and metaphase. PEA15-binding andphosphorylated DAPK1 promote its cytoplasmic retention.Phosphorylation at Ser-244 and Ser-246 as well asautophosphorylation at Thr-188 promote nuclear localization.
偶联

Non-conjugated
产品类别

Primary Antibody; Rabbit Polyclonal Antibody
宿主

Rabbit
反应物种

Human, Mouse(predicted: Rat, Chicken, Dog, Cow, Horse, Rabbit, Guinea Pig)
蛋白数据库

P63085
推荐稀释比例

WB: 1:500-2000;ELISA: 1:5000-10000;IHC-P: 1:100-500;IHC-F: 1:100-500;ICC: 1:100;IF: 1:100-500

应用

WB; ELISA; IHC-P; IHC-F; ICC; IF

性状

液体
组分

Supplied in 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 & 期限

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
运输条件

Shipping with blue ice.
同型

IgG
免疫原

KLH conjugated Synthesised phosphopeptide derived from mouse ERK1 around the phosphorylation site of Thr183/Tyr185: FL(p-T)E(p-Y)V
文件资料
抗体使用指南 (1083 KB)
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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phospho-ERK1 + 2 (Thr183/Tyr185) Antibody
目录号：
HY-P81156
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