Phospho-PTP1B (Ser378) 抗体 (YA1028)

Phospho-PTP1B (Ser378) Antibody (YA1028) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-PTP1B (Ser378).

The protein encoded by The related gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. The PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. The PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of The PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for The related gene.

P18031

Predicted band size: 50 kDa; Observed band size: 50 kDa

Affinity Purified

Non-conjugated

Phosphorylated

Signal Transduction

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Recombinant, Monoclonal

Rabbit

Human

WB: 1:500-1:1000; IHC: 1:50-1:100

WB, IHC-P

液体

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Endogenous

A synthetic phosphopeptide corresponding to residues surrounding Ser378 of human PTP1B