SirT2 抗体 (YA5213)

SirT2 Antibody (YA5213) is a mouse-derived and non-conjugated monoclonal antibody, targeting to SirT2. It can be applicated for WB, ICC/IF assays, in the background of human, mouse, rat.

SIRT2 是一种 NAD 依赖性蛋白去乙酰化酶，能够对组蛋白（如 H4K16ac、H3K56ac）、α-tubulin（如 Lys-40）以及多种关键转录因子（如 FOXO1、FOXO3、HIF1A、RELA、p53/TP53）进行去乙酰化。它参与调控细胞周期（如 G2/M 期转换、APC/C 复合体激活）、基因组稳定性、微管动力学、代谢通路（如磷酸戊糖途径 PPP、糖异生）、自噬和表观遗传修饰（如 H4K20me1 沉积）。在细菌感染（如 Listeria monocytogenes）或氧化应激时，SIRT2 通过去乙酰化作用调节转录活性和应激响应。此外，它还具有去豆蔻酰化（如 ARF6）和去棕榈酰化（如 KRAS）活性，影响膜定位。by similar：SIRT2 通过去乙酰化 FOXO3 促进其泛素化降解。

Q8IXJ6

Observed band size: 43 kDa

affinity chromatography.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human, Mouse, Rat

WB: 1:1000; ICC/IF: 1:50-200

WB, ICC/IF

液体

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Purified recombinant human SirT2 protein expressed in E.coli.