2. 抗体
  3. 一抗
  4. 单克隆抗体 重组抗体
  5. XBP1 抗体 (YA1424)

XBP1 抗体 (YA1424)

目录号: HY-P81679
COA 抗体使用指南 技术支持

XBP1 Antibody (YA1424) 是一个兔来源、无偶联标记、抗 XBP1 的 IgG 单克隆抗体。

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规格 价格 是否有货 数量
10 μL ￥470 In-stock
50 μL ￥1220 In-stock
100 μL ￥2000 In-stock
250 μL   询价  

* Please select Quantity before adding items.

Top Publications Citing Use of Products

【WB: 蛋白质免疫印迹; IHC-P: 石蜡切片样本的免疫组织化学; IHC-F: 冰冻切片样本的免疫组织化学; ICC/IF: 细胞免疫荧光; IF-Tissue: 组织免疫荧光; mIHC: 多重荧光免疫组化; IP: 免疫沉淀; ChIP: 染色质免疫沉淀; FC: 流式细胞术; ELISA: 酶联免疫吸附试验】

  • 生物活性

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描述

XBP1 Antibody (YA1424) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to XBP1.
研究背景

The related gene encodes a transcription factor that regulates MHC class II related genes by binding to a promoter element referred to as an X box. The related gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of The related gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target related genes during the recovery phase of ER stress. A pseudorelated gene of XBP1 has been identified and localized to chromosome 5.
基因 ID
蛋白数据库
中文名
XBP1 抗体 (YA1424)
同用名
XBP1; TREB5; XBP2; X-box-binding protein 1; XBP-1; Tax-responsive element-binding protein 5
分子量

Predicted band size: 29 kDa; Observed band size: 29 kDa
纯度

Affinity Purified
偶联

Non-conjugated
修饰

Unmodified
RRID
研究领域

Epigenetics and Nuclear Signaling
产品类别

Primary Antibody; Recombinant Rabbit Monoclonal Antibody
克隆性

Monoclonal, Recombinant
宿主

Rabbit
反应物种

Human, Mouse
推荐稀释比例

WB: 1:500-1:1000; IP: 1:20
应用

WB, IP
性状

液体
组分

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
保存条件 & 期限

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
运输条件

Shipping with blue ice.
同型

IgG
敏感性

Endogenous
免疫原

Recombinant protein of human XBP1 aa101-115.
数据库

Entrez Gene: 7494 Human ; 22433 Mouse ; 289754 Rat

SwissProt: P17861 Human ; O35426 Mouse ; Q9R1S4 Rat

OMIM: 612371 Human

文件资料

COA (193 KB)

抗体使用指南 (1083 KB)

XBP1 Antibody (YA1424) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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XBP1 Antibody (YA1424)
目录号：
HY-P81679
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