2. Apoptosis
  3. Apoptosis
  4. Anticancer agent 102

Anticancer agent 102 是丁卡因的衍生物。Anticancer agent 102 具有抗癌活性. Anticancer agent 102 诱导细胞凋亡。

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Anticancer agent 102 Chemical Structure

Anticancer agent 102 Chemical Structure

CAS No. : 2914922-86-2

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Anticancer agent 102 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anticancer agent 102 is a derivative of tetracaine. Anticancer agent 102 has anti-cancer activity. Anticancer agent 102 induces apoptosis[1].

体外研究
(In Vitro)

Anticancer agent 102 (compound 2s; 24 and 48 h) 具有抗肿瘤活性，对 Colo-205 和 HepG2 细胞的 IC50 值分别为 299.4 μM 和 62.9 μM[ 1].
Anticancer agent 102 (25 µM 和 50 µM; 24 h) 下调了 Colo-205 细胞中凋亡蛋白 PI3K 和 FoXO3a 的表达水平，上调了 PTEN 和 FoXO1 的表达水平。 Anticancer agent 102 (24 h) 上调 Bax 表达并诱导 HepG2 细胞系中的 caspase-3 依赖性细胞凋亡。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anticancer agent 102 相关抗体:

Cell Viability Assay[ 1]

Cell Line: Colo-205 and HepG2 cells
Concentration: 12.5, 25, 50, 100, 200, and 400 µM
Incubation Time: 24 and 48 hours
Result: Inhibited cell growth in a dose-dependent manner.

Western Blot Analysis[ 1]

Cell Line: Colo-205 cells
Concentration: 25 µM and 50 µM
Incubation Time: 24 hours
Result: down-regulated the expression level of apoptotic protein PI3K and FoXO3a, up-regulated the expression level of PTEN and FoXO1 in Colo-205 cells.
分子量

431.37

Formula

C20H19F6N3O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anticancer agent 102 相关分类

  • 摩尔计算器

  • 稀释计算器

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 1022914922-86-2Anticancer agent102Anticancer agent-102ApoptosisInhibitorinhibitorinhibit

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