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  3. Anticancer agent 105

Anticancer agent 105 是一种基于噻吩嘧啶支架的化合物,具有良好的安全性和抗癌性能。Anticancer agent 105 对黑色素瘤具有选择性毒性,并诱导细胞凋亡 (apoptosis)。Anticancer agent 105 在肺转移性黑色素瘤小鼠模型中也能显著抑制转移性结节。

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Anticancer agent 105 Chemical Structure

Anticancer agent 105 Chemical Structure

CAS No. : 2450987-57-0

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  • 生物活性

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生物活性

Anticancer agent 105 is a compound based on thienopyrimidine scaffold, with with good safety and anticancer properties. Anticancer agent 105 shows selective toxicity towards melanoma cancer, and induces apoptosis. And Anticancer agent 105 significantly inhibits the metastatic nodules, even in pulmonary metastatic melanoma mouse model[1].

体外研究
(In Vitro)

Anticancer agent 105 (compound 9cb) 显示出对癌细胞的选择性,同时它抑制癌细胞(B16–F10 黑色素瘤)和正常非癌性成纤维细胞 (MEF NF2) 的 IC50 分别为 2.41 μM 和 >100 μM[1]
Anticancer agent 105 (0.5-10 μM; 24 h) 显示出对癌细胞的毒性,并且 (5-20 μM; 48 h) 在 B16-F10 细胞中诱导细胞凋亡和坏死[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[1]

Cell Line: B16-F10 melanoma
Concentration: 0.5 μM, 1 μM, 5 μM, and 10 μM
Incubation Time: 24 h
Result: Exhibited very low toxicity or were non-toxic in the case of MEF NF2 cells in the range of concentration 0.2-55 μM.

Apoptosis Analysis[1]

Cell Line: B16-F10 melanoma
Concentration: 5 μM, 10 μM, 15 μM, and 20 μM
Incubation Time: 48 h
Result: Induced early apoptosis and resulted nuclear condensation.
体内研究
(In Vivo)

Anticancer agent 105 (compound 9cb) (9-9.5 mg/kg,每 3 天一次,持续 22 天;ip) 抑制携带 B16-F10 黑色素瘤的 C57BL/6 小鼠的转移性结节[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Pulmonary metastatic melanoma mouse model[1]
Dosage: I: 9-9.5 mg/kg; II: 42-4.6 mg/kg
Administration: IP; once daily every 3rd d for 22 d
Result: Decreased the number of metastatic nodules in mouse.
分子量

533.64

Formula

C25H24KN3O6S

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

Anticancer agent 105 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Anticancer agent 105
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