2. Anti-infection
  3. Fungal
  4. Antifungal agent 25

Antifungal agent 25 是一种有效的广谱抗真菌剂。Antifungal agent 25 对白色念珠菌和耐氟康唑的白色念珠菌均显示出抗真菌作用。Antifungal agent 25 在体内显示出代谢稳定性。

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Antifungal agent 25

Antifungal agent 25 Chemical Structure

CAS No. : 2566522-50-5

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Antifungal agent 25 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antifungal agent 25 is a potent broad-spectrum antifungal agent. Antifungal agent 25 shows antifungal effect against Candida albicans and fluconazole-resistant strain of Candida albicans. Antifungal agent 25 stable metabolic property in vivo[1].

体外研究
(In Vitro)

Antifungal agent 25 (compound A31) shows antifungal effect with MIC values of <0.03, <0.03, <0.03, 0.25, 0.5 µg/mL for Candida albicans (SC5314), Candida albicans ((GIM 2.194), Cryptococcus neoformans (GIM 2.209), Candida tropicalis (GIM 2.183), Aspergillus fumigatus (cgmcc 3.7795), respectively[1].
Antifungal agent 25 shows moderate antifungal activity with MIC values of 0.5, >64 µg/mL for strain CaR (fluconazole-resistant strain of Candida albicans) and strain 17# (fluconazole and itraconazole resistant strain of Candida albicans), respectively[1].
Antifungal agent 25 (0.015 mg/mL) blocks the biosynthesis of ergosterol by inhibiting the key enzyme lanosterol 14a-demethylase (CYP51)[1].
Antifungal agent 25 shows less likely to produce drug-drug interactions with IC50s of 4.47, 2.87, 1.04, 31.3, 10.1 µM for α-naphthoflavone (CYP1A2), sulfaphenazole (CYP2C9), ticlopidine (CYP2C19), quinidine (CYP2D6), and ketoconazole (CYP3A4), respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antifungal agent 25 相关抗体:
体内研究
(In Vivo)

Antifungal agent 25 (2 mg/kg; i.v.) exhibits stable metabolic property in SD rats[1].
Pharmacokinetic Parameters of Antifungal agent 25 in SD rats[1].

dose(mg/kg) C0(ng/mL) T1/2(h) Vdss(L/kg) Cl (mL/min/kg) AUC0-last (ng·h/mL) AUC0-inf (ng·h/mL)
2 mg/kg 482±108 3.34±2.37 10.3±3.12 69.4±18.8 483±137 5.5±136
SD rats; 2 mg/kg; i.v.[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SD rats[1]
Dosage: 2 mg/kg
Administration: I.v.
Result: Exhibited stable metabolic property in SD rats.
分子量

412.87

Formula

C20H14ClFN4OS
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antifungal agent 25 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Antifungal agent 252566522-50-5Antifungal agent25Antifungal agent-25FungalAntifungalbroad-spectrumCandida albicansSD ratsfluconazole-resistantCYP51stable metabolicInhibitorinhibitorinhibit

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