Antifungal agent 41 

Antifungal agent 41 (compound B01) is an antifungal agent. Antifungal agent 41 shows inhibitory effect on Candida albicans in virto and vivo. Antifungal agent 41 can be used for the research of invasive fungal infections^[1].

Antifungal agent 41 (0.25-128 μg/mL) shows antifungal activities to C.alb, C.alb (sc5314), C.gla, C.par, C.kru, C.zey, C.neo and A.f with MIC values of 2, 1, 8, 2, 8, 0.25, 4 and 1 μg/mL, respectively^[1].
Antifungal agent 41 (0-64 μg/mL; 24 h) shows antifungal activities against pathogenic fluconazole-resistant Candida albicans with MIC values of 2, 8, 4, 2 and 4 μg/mL for strain CaR, 17#, 632, 901 and 904, respectively^[1].
Antifungal agent 41 (0-64 μg/mL; 24 h) shows antifungal activities against Candida albicans with MFC value of 16, 8, 16, >64, 16, 2 and 4 μg/mL for C.alb, C.alb (sc5314), strain CaR, 17#, 632, 901 and 904, respectively^[1].
Antifungal agent 41 (0-1024 μg/mL; 1.5-24 h) inhibits C.alb ATCC SC5314 and CPCC400616 biofilms with SMIC₅₀s of 0.5 μg/mL and 0.5-4 μg/mL, with SMIC₈₀s of 4-32 μg/mL and 2-4 μg/mL, respectively^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antifungal agent 4 (6-12 mg/kg; i.p. once daily for 5 days) shows in vivo antifungal effects^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

638.14

C₂₂H₁₈Cl₄N₄Se₂

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Xu H, et al. Discovery of novel selenium-containing azole derivatives as antifungal agents by exploiting the hydrophobic cleft of CYP51. Eur J Med Chem. 2022 Aug 28;243:114707.  [Content Brief]