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  3. Antileishmanial agent-17

Antileishmanial agent-17 是一种香豆素杂化化合物,具有抗利什曼原虫作用 (IC50 <0.78 μM)。Antileishmanial agent-17 对正常 VERO 细胞是安全的。Antileishmanial agent-17 抑制叶酸途径。Antileishmanial agent-17 表现出最强效 IC50,对前鞭毛体为 0.40 μM,对无鞭毛体为 0.68 μM。

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Antileishmanial agent-17 Chemical Structure

Antileishmanial agent-17 Chemical Structure

CAS No. : 2934738-40-4

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  • 生物活性

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生物活性

Antileishmanial agent-17 is a coumarin hybrid compound with antileishmanial effects (IC50 <0.78 μM). Antileishmanial agent-17 is safe to normal VERO cells. Antileishmanial agent-17 binds to folate pathway enzymes pteridine reductase and DHFR-TS. And Antileishmanial agent-17 shows the most potent with IC50 value of 0.40 μM against promastigote and 0.68 μM against amastigote, respectivley.

体外研究
(In Vitro)

Antileishmanial agent-17 (compound 14b) 抑制叶酸途径,对叶酸的抑制率为 82% 和 91%,对亚叶酸的抑制率为 88% 和 91%,分别为 20 μM 和 100 μM[1]
Antileishmanial agent-17 对非洲绿猴肾细胞 (VERO 细胞) 表现出微弱的细胞毒性,CC50 为 244.3 μM[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

511.61

Formula

C27H37N5O5

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

Antileishmanial agent-17 相关分类

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