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  3. Antioxidant agent-3

Antioxidant agent-3 (Compound 14q) 是一种抗氧化剂,具有有效的 DPPH 自由基清除活性和 ABTS+ 清除活性,IC50 分别为 26.58 和 30.31 μM。Antioxidant agent-3 (Compound 14q) 作用于 H2O2 处理的 HepG2 细胞,可增加活性氧 (ROS)、超氧化物歧化酶 (SOD) 和谷胱甘肽 (GSH),并减少乳酸脱氢酶(LDH)。

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Antioxidant agent-3 Chemical Structure

Antioxidant agent-3 Chemical Structure

CAS No. : 2710376-48-8

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antioxidant agent-3 (Compound 14q), an potent antioxidant, displays potent DPPH radicals scavenging activity and ABTS+ scavenging activity with IC50s of 26.58 and 30.31 μM, respectively. Antioxidant agent-3 (Compound 14q) increases reactive oxygen species (ROS), superoxide dismutase (SOD) and glutathione (GSH), and reduced lactate dehydrogenase (LDH) in H2O2-treated HepG2 cells[1].

体外研究
(In Vitro)

Antioxidant agent-3 (Compound 14q) exhibits good activity in DPPH radicals scavenging and ABTS +• scavenging with the values of IC50 is 26.58 μM and 30.31 μM respectively[1].
Antioxidant agent-3 shows low cytotoxicity in human normal WI-38 (IC50 > 100 μM) and GES (IC50 > 200 μM) cells[1].
Antioxidant agent-3 can enhance viability of H2O2-induced HepG2 cells[1].
Antioxidant agent-3 decreases the apoptotic percentage of HepG2 cells[1].
Antioxidant agent-3 reduces the ROS produce and LDH release, improves GSH and SOD levels in H2O2-treated HepG2 cells, and exhibits more stability in methanol solution[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[1]

Cell Line: WI-38 and GES cells line
Concentration: 200, 100, 50, 25 and 12.5 μM
Incubation Time: 48 h
Result: Showed less toxicity in hemolysis assay and weaker antiproliferative effects.

Cell Viability Assay[1]

Cell Line: H2O2-damaged WI-38 and HepG2 cells
Concentration: 50, 25 and 12.5 μM
Incubation Time: 1 h
Result: Increased cells viability of H2O2-indcued cells and protected the H2O2-indcued cells against injury.

Apoptosis Analysis[1]

Cell Line: H2O2-damaged HepG2 cells
Concentration: 50, 25 and 12.5 μM
Incubation Time: 1 h
Result: Protect the H2O2-injured HepG2 cells against apoptosis through antioxidant effect.
分子量

358.30

Formula

C18H14O8

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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