2. Anti-infection
  3. Parasite
  4. Antiparasitic agent-28

Antiparasitic agent-28 是一种口服活性的、选择性抑制 Toxoplasma gondii 苯丙氨酸 tRNA 合成酶 (TgcPheRS) 的抑制剂，具有血脑屏障渗透能力。Antiparasitic agent-28 抑制 T. gondii 速殖子 (TgME49-Fluc 株) 的生长 (EC50 = 1 nM) 以及碱性诱导的 T. gondii 缓殖子 (Tg68nLuc 株) (EC50 = 3 nM) 和富含谷氨酰胺培养基诱导的缓殖子 (EC50 = 0.1 nM)。Antiparasitic agent-28 在感染 TgME49-Fluc 速殖子的小鼠中显示出强大的抗弓形虫病疗效。Antiparasitic agent-28 可用于研究 Toxoplasma gondii 感染。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Antiparasitic agent-28

Antiparasitic agent-28 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Antiparasitic agent-28 相关抗体

Top Publications Citing Use of Products

查看 Parasite 亚型特异性产品:

查看所有亚型
Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antiparasitic agent-28 is an orally active, selective inhibitor of Toxoplasma gondii phenylalanine tRNA synthetase (TgcPheRS) with blood-brain barrier penetration. Antiparasitic agent-28 inhibits the growth of T. gondii tachyzoites (TgME49-Fluc strain) an (EC50 = 1 nM) and T. gondii bradyzoites (Tg68nLuc strain) induced by alkaline (EC50 = 3 nM) and glutamine-rich medium (EC50 = 0.1 nM). Antiparasitic agent-28 demonstrates potent anti-toxoplasmosis efficacy in mice infected with TgME49-Fluc tachyzoites. Antiparasitic agent-28 can be used for the study of Toxoplasma gondii infection[1].

体外研究
(In Vitro)

Antiparasitic agent-28 (Compound 12) (72 h) 强效抑制 Toxoplasma gondii 速殖子 (TgME49-Fluc 株) 的生长 (EC50 = 1 nM, EC90 = 2 nM)[1]。
Antiparasitic agent-28 (96 h) 有效抑制碱性诱导的 T. gondii 缓殖子 (Tg68nLuc 株) (EC50 = 3 nM) 和富含谷氨酰胺培养基诱导的缓殖子 (EC50 = 0.1 nM)[1]。
Antiparasitic agent-28 对人肝细胞 HepG2 细胞 (CC50 = 0.99 μM, SI = CC50/EC50 = 1447) 和人单核细胞 THP-1 细胞 (CC50 = 0.25 μM, SI = 374) 表现出低毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antiparasitic agent-28 相关抗体:
体内研究
(In Vivo)

Antiparasitic agent-28 (Compound 12) (3 mg/kg，口服，每日两次，7 天) 可阻止感染 TgME49-Fluc 速殖子的 C57/BL6 雌性小鼠引起的慢性感染[1]。
Antiparasitic agent-28 (3 mg/kg，口服，每日两次，14 天) 显著延长感染 TgME49-Fluc 速殖子的干扰素 γ 受体 1 敲除小鼠的存活时间[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57/BL6 female mice (6-8 weeks old) infected with 300 TgME49-Fluc tachyzoites via intraperitoneal injection[1]
Dosage: 3 mg/kg
Administration: p.o., twice daily, 7 days
Result: Prevented chronic infection (no parasite outgrowth in brain homogenate).
Did not cause significant changes in plasma levels of liver and kidney function indicators (ALT, AST, BUN, creatinine).
Animal Model: Interferon gamma receptor 1 knockout (Ifngr1⁻/⁻) mice infected with 300 TgME49-Fluc tachyzoites via i.p. injection[1]
Dosage: 3 mg/kg
Administration: p.o., twice daily, 14 days
Result: Prolonged the survival time (longer than that of the sulfadiazine-treated group).
分子量

481.59

Formula

C30H31N3O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antiparasitic agent-28 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antiparasitic agent-28Antiparasitic agent28Antiparasitic agent 28ParasiteToxoplasma gondiiinfectionTgcPheRSTgME49-Fluc strainTg68nLuc strainInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Antiparasitic agent-28
目录号：
HY-175648
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z