1. Metabolic Enzyme/Protease
  2. Mitochondrial Metabolism
  3. Antiproliferative agent-12

Antiproliferative agent-10 (compound 1) 是一种抗肿瘤钌(II)-三吡唑基甲烷复合物,可通过抑制线粒体钙摄入抑制癌细胞的生长。

MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Antiproliferative agent-12 Chemical Structure

Antiproliferative agent-12 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

注册 MCE会员完成审核
即刻享有 积分商城 300 专属积分

Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antiproliferative agent-10 (compound 1) is an anti-tumour ruthenium(II)-tris-pyrazolylmethane complex that inhibits the growth of cancer cells by inhibiting mitochondrial calcium uptake[1].

体外研究
(In Vitro)

Antiproliferative agent-10 (compound 1) (1.5-5.8 μM, 72 h) has significantly anti-cancer cell proliferative activity and effectively induces apoptosis in HCT116 cells[1].
Antiproliferative agent-10 (15 μM, 24 h) shows HCT116 cell survival rates of 93% to 97% and ruthenium content of cell was 145.1 ng/106 cells, so that it can accumulate efficiently in the cells and promote their biological activity[1].
Antiproliferative agent-10 (3-10 μM, 5 h) can cause mitochondrial depolarization in a concentration-dependent manner and inhibit mitochondrial calcium uptake[1].
Antiproliferative agent-10 can inhibit the formation and growth of spheroids of HCT116 cells with an IC50 value of 2.5 μM, approximately 18-fold more effective than cisplatin and almost completely disintegrate of the spheroids[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: MCF-7 (breast), HeLa (cervical), 518A2 (melanoma), HCT116 (colon), RD (rhabdomyosarcoma)
Concentration: 1.5-5.8 μM
Incubation Time: 72 hours
Result: Inhibited the proliferation of MCF-7, HeLa, 518A2, HCT116 and RD with the IC50 values of 2.4, 4, 2.6, 1.5 and 2.2 μM, respectively.
分子量

910.79

Formula

C46H40Cl2N6P2Ru

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

Antiproliferative agent-12 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
Antiproliferative agent-12
目录号:
HY-150969
需求量: