1. Apoptosis
  2. Apoptosis
  3. Antiproliferative agent-43

Antiproliferative agent-43 (Compound e4 ) 对肿瘤细胞有明显的细胞毒作用,通过在 G1 期停止细胞周期而导致细胞凋亡。

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Antiproliferative agent-43 Chemical Structure

Antiproliferative agent-43 Chemical Structure

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Customer Review

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antiproliferative agent-43 (Compound e4 ) has notable cytotoxic effects against cancer cell lines and causes apoptosis by stopping the cell cycle at G1 phase[1].

体外研究
(In Vitro)

Antiproliferative agent-43 (0, 1.23, 2.45 , 2.90 μM, 48 h) 在 K562 细胞中引起 G1 期细胞周期阻滞,并伴有细胞核形态异常[1]
Antiproliferative agent-43 (0, 1.23, 2.45 , 2.90 μM, 48 h) 在 K562 细胞中通过线粒体途径诱导细胞凋亡[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis[1]

Cell Line: K562
Concentration: 0, 1.23, 2.45 , 2.90 μM
Incubation Time: 48h
Result: Induced G1 phase cell cycle arrest in the K562 cell line.

Apoptosis Analysis[1]

Cell Line: K562
Concentration: 0, 1.23, 2.45 , 2.90 μM
Incubation Time: 48h
Result: The apoptotic cells induced by antiproliferative agent-43 increased from 6.35% in the negative control to 13.36, 37.99, and 64.94%, with a concentration-dependent manner.
分子量

772.07

Formula

C45H57NO6S2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

Antiproliferative agent-43 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Antiproliferative agent-43
目录号:
HY-155413
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